Recent advances in functional activatable probes for oncological surgery: Illuminating precision or hindering clinical translation?

IF 5.9 2区 医学 Q1 CHEMISTRY, MEDICINAL
Jialiang Lu , Weihao Zhuang , Xiaowu Dong , Haiyan Yang
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引用次数: 0

Abstract

Fluorescence-guided surgery has advanced significantly by developing activatable probes that selectively illuminate tumors by responding to microenvironmental biomarkers, minimizing background noise, and improving tumor-to-normal ratios. Unlike conventional “Always-on” probes, activatable designs leverage tumor-specific triggers—such as enzymatic activity, acidic pH, hypoxia, or redox imbalances—to achieve precise fluorescence unmasking. Recent innovations include single-stimuli probes with rapid activation kinetics for real-time intraoperative imaging and multi-stimuli systems to enhance specificity. Targeted strategies for integrating ligands for folate receptors, integrins, or PSMA further improve tumor accumulation. Despite preclinical success, clinical translation remains limited. The field now prioritizes interdisciplinary collaboration to address probe stability, safety, and reproducibility challenges, aiming to bridge the gap between molecular innovation and surgical practicality. By harmonizing probe design with clinical needs, activatable fluorescence imaging promises to redefine precision in oncological surgery, though scalability demands concerted efforts in probe rational design and technology integration.

Abstract Image

Abstract Image

肿瘤外科功能激活探针的最新进展:阐明精确性还是阻碍临床转化?
通过开发可激活探针,荧光引导手术已经取得了重大进展,该探针通过响应微环境生物标志物,最小化背景噪声,提高肿瘤与正常比率,选择性地照亮肿瘤。与传统的“永远在线”探针不同,可激活设计利用肿瘤特异性触发因素(如酶活性、酸性pH值、缺氧或氧化还原失衡)来实现精确的荧光揭露。最近的创新包括具有快速激活动力学的单刺激探针,用于实时术中成像和多刺激系统,以提高特异性。靶向策略整合叶酸受体、整合素或PSMA配体进一步改善肿瘤积累。尽管临床前取得了成功,但临床翻译仍然有限。该领域现在优先考虑跨学科合作,以解决探针的稳定性、安全性和可重复性挑战,旨在弥合分子创新与手术实用性之间的差距。通过将探针设计与临床需求相协调,可激活荧光成像有望重新定义肿瘤手术的精度,尽管可扩展性需要在探针合理设计和技术集成方面协同努力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.70
自引率
9.00%
发文量
863
审稿时长
29 days
期刊介绍: The European Journal of Medicinal Chemistry is a global journal that publishes studies on all aspects of medicinal chemistry. It provides a medium for publication of original papers and also welcomes critical review papers. A typical paper would report on the organic synthesis, characterization and pharmacological evaluation of compounds. Other topics of interest are drug design, QSAR, molecular modeling, drug-receptor interactions, molecular aspects of drug metabolism, prodrug synthesis and drug targeting. The journal expects manuscripts to present the rational for a study, provide insight into the design of compounds or understanding of mechanism, or clarify the targets.
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