Martin Nigríni,Filip Uhlík,Ivana Císařová,Jan Veselý
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引用次数: 0
Abstract
We report an enantioselective Pictet-Spengler-type reaction enabled by a cost-effective and readily available helically chiral cyclopentadiene (PCCP) catalyst. This methodology, conducted under mild reaction conditions, facilitates the synthesis of a novel class of chiral 4,5-dihydropyrrolo[1,2-a]quinoxalines (DHPQs) characterized by enhanced resistance to aromatization due to intramolecular hydrogen bonding. Additionally, the protocol exhibits broad substrate compatibility and demonstrates significant synthetic versatility.
期刊介绍:
Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.