Integration of chemical and physical inputs for monitoring metabolites and cardiac signals in diabetes

IF 26.8 1区医学 Q1 ENGINEERING, BIOMEDICAL

Nature Biomedical Engineering Pub Date : 2025-07-02 DOI:10.1038/s41551-025-01439-z

An-Yi Chang, Muyang Lin, Lu Yin, Maria Reynoso, Shichao Ding, Ruixiao Liu, Yuma Dugas, Ana Casanova, Geonho Park, Zhengxing Li, Hao Luan, Nelly Askarinam, Fangyu Zhang, Sheng Xu, Joseph Wang

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Abstract

The development of closed-loop systems towards effective management of diabetes requires the inclusion of additional chemical and physical inputs that affect disease pathophysiology and reflect cardiovascular risks in patients. Comprehensive glycaemic control information should account for more than a single glucose signal. Here, we describe a hybrid flexible wristband sensing platform that integrates a microneedle array for multiplexed biomarker sensing and an ultrasonic array for blood pressure, arterial stiffness and heart-rate monitoring. The integrated system provides a continuous evaluation of the metabolic and cardiovascular status towards improving glycaemic control and alerting patients to cardiovascular risks. The multimodal platform offers continuous glucose, lactate and alcohol monitoring, along with simultaneous ultrasonic measurements of blood pressure, arterial stiffness and heart rate, to support understanding of the interplay between interstitial fluid biomarkers and physiological parameters during common activities. By expanding the continuous monitoring of patients with diabetes to additional biomarkers and key cardiac signals, our integrated multiplexed chemical–physical health-monitoring platform holds promise for addressing the limitations of existing single-modality glucose-monitoring systems towards enhanced management of diabetes and related cardiovascular risks.

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整合用于监测糖尿病代谢产物和心脏信号的化学和物理输入

为有效管理糖尿病而开发的闭环系统需要纳入影响疾病病理生理和反映患者心血管风险的额外化学和物理输入。综合血糖控制信息应考虑到不止一个葡萄糖信号。在这里，我们描述了一种混合柔性腕带传感平台，该平台集成了用于多路生物标志物传感的微针阵列和用于血压、动脉硬度和心率监测的超声波阵列。该综合系统为改善血糖控制和提醒患者心血管风险提供了持续的代谢和心血管状态评估。多模式平台提供连续的葡萄糖、乳酸和酒精监测，以及同时超声测量血压、动脉僵硬度和心率，以支持了解日常活动中间质液生物标志物和生理参数之间的相互作用。通过将对糖尿病患者的持续监测扩展到更多的生物标志物和关键的心脏信号，我们的综合多路化学-物理健康监测平台有望解决现有单模态血糖监测系统的局限性，从而增强对糖尿病和相关心血管风险的管理。

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来源期刊

Nature Biomedical Engineering Medicine-Medicine (miscellaneous)

CiteScore

45.30

自引率

1.10%

发文量

138

期刊介绍： Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.