Bioinspired Immunomodulatory Scaffold Based on Mineralized Lotus Stalks Laden with MnCO Microspheres for Accelerated Bone Regeneration

IF 26.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials Pub Date : 2025-07-02 DOI:10.1002/adma.202502919

Jianqiu Yang, Lei Du, Hui Du, Ganghua Yang, Weicong Fu, Liang Zhai, Zhuoyuan Yang, Shixuan Chen, Qining Yang, Wenbing Wan

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引用次数: 0

Abstract

Bone regeneration remains a significant clinical challenge due to the complexity of the bone healing process and the need for biomaterials that provide both structural support and immunomodulatory functions. Here, a bioinspired immunomodulatory scaffold is developed, composed of mineralized decellularized lotus stalks (MDL) integrated with manganese carbonyl (MnCO)‐loaded mesoporous polydopamine (mPDA) microspheres (MM@MDL3). This scaffold mimics the hierarchical architecture of natural bone while offering controlled CO and Mn2+ release, promoting M2 macrophage polarization, reducing inflammation, and enhancing osteogenesis. In vitro studies demonstrate that MM@MDL3 effectively promotes mesenchymal stem cell (MSC) differentiation by activating the BMP2/SMAD/RUNX2 pathway. In vivo rat calvarial defect models confirm significant bone regeneration, with increased bone volume, enhanced vascularization, and reduced osteoclastogenesis. These results demonstrate MM@MDL3 as a promising strategy for large‐segment bone defect repair by integrating a biomimetic structure with immunomodulatory and osteogenic properties. The proposed scaffold has great potential for treating clinical large‐segment bone defects.

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基于矿化莲杆负载MnCO微球的生物免疫调节支架加速骨再生

由于骨愈合过程的复杂性以及对提供结构支持和免疫调节功能的生物材料的需求，骨再生仍然是一个重大的临床挑战。本研究开发了一种生物启发的免疫调节支架，由矿化脱细胞莲杆（MDL）与负载羰基锰（MnCO）的介孔聚多巴胺（mPDA）微球结合（MM@MDL3）组成。该支架模拟了天然骨的分层结构，同时提供可控的CO和Mn2+释放，促进M2巨噬细胞极化，减少炎症，促进成骨。体外研究表明MM@MDL3通过激活BMP2/SMAD/RUNX2通路有效促进间充质干细胞（MSC）分化。体内大鼠颅骨缺损模型证实了显著的骨再生，骨体积增加，血管化增强，破骨细胞生成减少。这些结果表明MM@MDL3通过整合具有免疫调节和成骨特性的仿生结构，是修复大节段骨缺损的一种很有前途的策略。所提出的支架在治疗临床大节段骨缺损方面具有很大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Materials 工程技术-材料科学：综合

CiteScore

43.00

自引率

4.10%

发文量

2182

审稿时长

2 months

期刊介绍： Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.