Effect of Lactobacillus reuteri probiotic on gingival index and Interleukin-1β levels of children with thalassemia experiencing gingivitis.

Abstract

Context: Thalassemia is a genetic blood disorder caused by gene mutation leading to chronic anemia, and patients will need routine blood transfusions as a lifetime supportive therapy. Previous studies show high prevalence of periodontal disease in patients who receive routine blood transfusions. Recent studies found probiotic supplementation as an adjuvant therapy in managing periodontal disease.

Aims: This study aimed to analyze the effect of Lactobacillus reuteri probiotic consumption on gingival index and salivary interleukin-1β levels of children with thalassemia experiencing gingivitis.

Settings and design: This was an evaluative study conducted at a tertiary care hospital in Jakarta, Indonesia.

Participants and methods: In this study, 16 children aged 6-12 with thalassemia major were recruited in Instalasi Pelayanan Terpadu Kesehatan Ibu dan Anak RSUPN Dr. Cipto Mangunkusumo. Dental health education and Lactobacillus L. reuteri probiotics supplementation 1×/day for 14 days were given to all participants. The gingival index by Lobene was measured at baseline and day 14. Salivary interleukin-1β levels were tested by ELISA Kit in a laboratory.

Statistical analysis used: Dependent t-test.

Results: There was a significant difference in gingival index and salivary interleukin-1β levels of children with thalassemia after consuming L. reuteri probiotics for 14 days.

Conclusion: L. reuteri probiotic consumption for 14 days significantly reduced the gingival index and salivary interleukin-1β levels of children with thalassemia experiencing gingivitis.