Prediction of brain age using structural magnetic resonance imaging: A comparison of clinical validity of publicly available software packages.

Ruben P Dörfel, Brice Ozenne, Melanie Ganz, Jonas E Svensson, Pontus Plavén-Sigray
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Abstract

Brain age estimated from structural magnetic resonance images is commonly used as a biomarker of biological aging and brain health. Ideally, as a clinically valid biomarker, brain age should indicate the current state of health and be predictive of future disease onset and detrimental changes in brain biology. In this preregistered study, we evaluated and compared the clinical validity, i.e., diagnostic and prognostic performance, of six publicly available brain age prediction packages using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Baseline brain age differed significantly between groups consisting of individuals with normal cognitive function, mild cognitive impairment, and Alzheimer's disease for all packages, but with comparable performance to estimates of gray matter volume. Further, brain age estimates were not centered around zero for cognitively normal subjects and showed considerable variation between packages. Finally, brain age was only weakly correlated with disease onset, memory decline, and gray matter atrophy within four years from baseline in individuals without neurodegenerative disease. The systematic discrepancy between chronological age and brain age among healthy subjects, combined with the weak associations between brain age and longitudinal changes in memory performance or gray matter volume, suggests that the current brain age estimates have limited clinical validity as a biomarker for biological aging.

使用结构磁共振成像预测脑年龄:公开可用软件包的临床有效性比较。
从结构磁共振图像中估计的脑年龄通常被用作生物老化和脑健康的生物标志物。理想情况下,作为临床有效的生物标志物,脑年龄应该表明当前的健康状态,并预测未来的疾病发作和脑生物学的有害变化。在这项预注册的研究中,我们使用来自阿尔茨海默病神经影像学倡议(ADNI)的数据,评估并比较了六个公开可用的脑年龄预测包的临床有效性,即诊断和预后表现。基线脑年龄在由正常认知功能、轻度认知障碍和阿尔茨海默病患者组成的组之间存在显著差异,但与灰质体积估计值具有可比性。此外,对于认知正常的受试者,大脑年龄估计值并不是以零为中心,而且在不同的测试包之间显示出相当大的差异。最后,在没有神经退行性疾病的个体中,脑年龄与疾病发病、记忆力下降和灰质萎缩在基线后的4年内只有微弱的相关性。健康受试者的实足年龄和脑年龄之间的系统性差异,以及脑年龄与记忆表现或灰质体积的纵向变化之间的微弱关联,表明目前的脑年龄估计作为生物衰老的生物标志物的临床有效性有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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