Rongfang Liu , Qiaoying Cai , Yongle Li , Xuguang Zhang
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引用次数: 0
Abstract
Objectives
Penehyclidine hydrochloride, a common anticholinergic drug, shows protective effects on ischemia-reperfusion injury (IRI) in various organs. However, the effects of penehyclidine hydrochloride on lung IRI induced by lung transplantation (LTx) have not been known, especially during the cold ischemia phase. Therefore, this study aimed to explore the effect of penehyclidine hydrochloride on lung IRI in a rat model of LTx.
Material and methods
Rats were randomly divided into sham group, control group, and penehyclidine hydrochloride group (PHC group). Rats in the sham group only underwent thoracotomies without LTx. Rats in the C group and PHC group established LTx model and received no treatment or penehyclidine hydrochloride respectively during the cold ischemia phase. At 120 minutes after LTx, the blood gas analysis, wet to dry ration (W/D), inflammatory reaction, oxidative stress injury, and lung structure were detected. Additionally, the type II alveolar epithelial cells observed by transmission electron microscopy were also explored.
Results
Compared with C group, the oxygenation, W/D, inflammatory markers, oxidative stress markers and lung structure in the C group and PHC group deteriorated, which improved in the PHC group compared with those in the C group (P < .05). Additionally, the type II alveolar epithelial cells were also less damaged in the PHC group compared with the C group (P < .05).
Conclusions
Penehyclidine hydrochloride applied during the cold ischemia phase improved lung IRI caused by LTx via inhibiting inflammatory response and oxidative stress injury, and maintained the integrity of organizational structure in the type II alveolar epithelial cells.
期刊介绍:
Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication.
The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics.
Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board.
Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.