An Orthogonal Way of Writing the Tubulin Code.

Abstract

The Elongator complex has long been characterized for its role in tRNA modification and modulation of protein translation. Beyond these established functions, recent findings reveal an unexpected role for Elongator in directly interacting and tuning microtubule dynamics and properties, broadening its biological significance in eukaryotic cells. This places Elongator among a growing number of RNA-binding proteins, such EIF4A3, that have been shown to modulate the microtubule cytoskeleton.