{"title":"Sleep Deprivation Does Not Affect Vestibulo-Ocular Reflex Gain but Deteriorates Vestibular Adaptation Ability?","authors":"Hadas Ben-Rubi Shimron, Yoav Gimmon","doi":"10.1097/AUD.0000000000001685","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>To assess the effect of acute sleep deprivation on the physiologic, adaptive, and behavioral properties of vestibulo-ocular reflex (VOR) compared with a full night's sleep.</p><p><strong>Design: </strong>Seventeen volunteers (age range 32 to 42 years, 7 females) were recruited into this crossover study and evaluated for 2 nights, first after normal sleep, and then after 24 hours of sleep deprivation. Tests included physiological VOR assessments by means of the Video Head Impulse Test in four random conditions consisting of far and near targets and performed with active (self-induced) and passive head movements. The adaptation ratio was calculated as the amount of change between VOR gains in near- and far-target conditions (near-VOR gain/far-VOR gain × 100). Behavioral VOR was evaluated by a computerized dynamic visual acuity test.</p><p><strong>Results: </strong>Fourteen participants completed the protocol (age range 34 to 42 years, 5 females). The VOR gain did not change following sleep deprivation for the passive head rotations or any of the tested conditions (paired t test >0.05). The VOR gain increased significantly in the middle of the night during the sleep deprivation: far-target-passive impulse (analysis of variance [ANOVA] F = 8.67, p = 0.001, 9 p.m. to 2 a.m.p = 0.001 post hoc); near-target active-impulse (ANOVA F = 4.66, p = 0.019, 2 a.m. to 6 a.m.p = 0.021 post hoc). The magnitude of VOR gain adaptation significantly reduced 7.1% after sleep deprivation for active head rotation (repeated measure ANOVA F = 5.212, p = 0.013). Measures of the behavioral VOR (difference between static and dynamic visual acuity) was not different between conditions (Wilcoxon signed-rank test, p value >0.05).</p><p><strong>Conclusion: </strong>Sleep deprivation reduced adaptative capacity of the VOR gain without affecting the physiologic or behavioral function of the VOR. The increase in VOR gain during the night might be explained by circadian rhythm involvement.</p>","PeriodicalId":55172,"journal":{"name":"Ear and Hearing","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ear and Hearing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/AUD.0000000000001685","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AUDIOLOGY & SPEECH-LANGUAGE PATHOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: To assess the effect of acute sleep deprivation on the physiologic, adaptive, and behavioral properties of vestibulo-ocular reflex (VOR) compared with a full night's sleep.
Design: Seventeen volunteers (age range 32 to 42 years, 7 females) were recruited into this crossover study and evaluated for 2 nights, first after normal sleep, and then after 24 hours of sleep deprivation. Tests included physiological VOR assessments by means of the Video Head Impulse Test in four random conditions consisting of far and near targets and performed with active (self-induced) and passive head movements. The adaptation ratio was calculated as the amount of change between VOR gains in near- and far-target conditions (near-VOR gain/far-VOR gain × 100). Behavioral VOR was evaluated by a computerized dynamic visual acuity test.
Results: Fourteen participants completed the protocol (age range 34 to 42 years, 5 females). The VOR gain did not change following sleep deprivation for the passive head rotations or any of the tested conditions (paired t test >0.05). The VOR gain increased significantly in the middle of the night during the sleep deprivation: far-target-passive impulse (analysis of variance [ANOVA] F = 8.67, p = 0.001, 9 p.m. to 2 a.m.p = 0.001 post hoc); near-target active-impulse (ANOVA F = 4.66, p = 0.019, 2 a.m. to 6 a.m.p = 0.021 post hoc). The magnitude of VOR gain adaptation significantly reduced 7.1% after sleep deprivation for active head rotation (repeated measure ANOVA F = 5.212, p = 0.013). Measures of the behavioral VOR (difference between static and dynamic visual acuity) was not different between conditions (Wilcoxon signed-rank test, p value >0.05).
Conclusion: Sleep deprivation reduced adaptative capacity of the VOR gain without affecting the physiologic or behavioral function of the VOR. The increase in VOR gain during the night might be explained by circadian rhythm involvement.
期刊介绍：
From the basic science of hearing and balance disorders to auditory electrophysiology to amplification and the psychological factors of hearing loss, Ear and Hearing covers all aspects of auditory and vestibular disorders. This multidisciplinary journal consolidates the various factors that contribute to identification, remediation, and audiologic and vestibular rehabilitation. It is the one journal that serves the diverse interest of all members of this professional community -- otologists, audiologists, educators, and to those involved in the design, manufacture, and distribution of amplification systems. The original articles published in the journal focus on assessment, diagnosis, and management of auditory and vestibular disorders.
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