Effects of close surgical margins on prognosis and recurrence of oral squamous cell carcinoma.

IF 1.4 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of the Korean Association of Oral and Maxillofacial Surgeons Pub Date : 2025-06-30 DOI:10.5125/jkaoms.2025.51.3.161

Kavitha Prasad, A Nityasri, Jugal Ashok Toprani, Shashank Madhusudan

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Abstract

Objectives: To assess the relationships of close surgical margins with recurrence and prognosis of oral squamous cell carcinoma (OSCC).

Materials and methods: This retrospective study consisted of 198 patients who were diagnosed with OSCC based on histopathology. All patients underwent wide local tumor resection and neck dissection, followed by or preceded by chemotherapy and/or radiotherapy. The tumor variables assessed were the pathological stage of disease, involvement site, tumor size, margin status, tumor differentiation, bone involvement if any, presence of lymphovascular or perineural invasion, adjuvant therapies including chemotherapy and radiotherapy, lymph node involvement, and ratio.

Results: The outcome of the disease based on margins was statistically significant, with close mar- gins associated with increased risk of disease fatality. Recurrence was associated with close margins, followed by adequate margins, and the relation-ship was significant within the first 2 years. Tumor stage and size significantly correlated with margin status. Close surgical margins correlated with one positive lymph node.

Conclusion: Close surgical margins are strong predictors for determining prognosis of OSCC.

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闭合切缘对口腔鳞状细胞癌预后及复发的影响。

目的：探讨口腔鳞状细胞癌（OSCC）手术切缘与复发及预后的关系。材料和方法：本回顾性研究包括198例经组织病理学诊断为OSCC的患者。所有患者均行局部肿瘤切除术和颈部清扫，随后或之前行化疗和/或放疗。评估的肿瘤变量包括疾病的病理分期、受累部位、肿瘤大小、边缘状态、肿瘤分化、骨受累（如果有）、淋巴血管或神经周围浸润的存在、包括化疗和放疗在内的辅助治疗、淋巴结受累和比例。结果：基于边缘的疾病结局具有统计学意义，边缘接近与疾病死亡风险增加相关。复发与切缘紧密相关，其次是切缘充足，并且在前2年内这种关系是显著的。肿瘤分期、大小与切缘状态显著相关。闭合手术缘与1个阳性淋巴结相关。结论：手术切缘紧密是判断OSCC预后的重要预测因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Korean Association of Oral and Maxillofacial Surgeons DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

2.00

自引率

10.00%

发文量

期刊介绍： Journal of the Korean Association of Oral and Maxillofacial Surgeons (J Korean Assoc Oral Maxillofac Surg) is the official journal of the Korean Association of Oral and Maxillofacial Surgeons. This bimonthly journal offers high-quality original articles, case series study, case reports, collective or current reviews, technical notes, brief communications or correspondences, and others related to regenerative medicine, dentoalveolar surgery, dental implant surgery, head and neck cancer, aesthetic facial surgery/orthognathic surgery, facial injuries, temporomandibular joint disorders, orofacial disease, and oral pathology. J Korean Assoc Oral Maxillofac Surg is of interest to oral and maxillofacial surgeons and dental practitioners as well as others who are interested in these fields.