Mechanical cues orchestrate monocyte behavior in immune regulation and disease.

IF 4.1 3区 医学 Q1 ENGINEERING, BIOMEDICAL
APL Bioengineering Pub Date : 2025-06-27 eCollection Date: 2025-06-01 DOI:10.1063/5.0268234
Yifan Lin, Hardik Makkar, Shuchen Zhang, Bingling Chen, Chaoning Zhan, Kyle Vining
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引用次数: 0

Abstract

Monocytes, key mediators of innate immunity, exhibit remarkable sensitivity to mechanical cues such as extracellular matrix (ECM) stiffness, substrate rigidity, shear stress, compression, and hydrostatic pressure, which shape their activation, differentiation, and functional polarization. Monocytes develop from the bone marrow and populate the vasculature throughout the body. During inflammation, they are recruited to injured or diseased tissues by chemokines and proinflammatory cytokines, modulating local immune responses during embryonic development and adulthood via mechanosensing and mechanotransduction pathways. This review synthesizes recent advances in monocyte mechanobiology. It highlights how the bone marrow ECM mechanics orchestrates myelopoiesis, the role of endothelium and hemodynamic forces in migration, and how tissue mechanics influences monocyte fate in chronic inflammation, fibrosis, and cancer. We discuss the mechanosensitive pathways that govern monocyte behavior in health and disease and therapeutic opportunities that emerge from targeting these mechanisms via biomaterial approaches. Additionally, future directions toward developing mechanotherapy for immune modulation are discussed. By bridging mechanobiology and immunology, this review underscores the potential of mechanical cues as therapeutic targets to reprogram monocyte behavior in disease.

机械信号在免疫调节和疾病中协调单核细胞的行为。
单核细胞是先天免疫的关键介质,对细胞外基质(ECM)刚度、底物刚度、剪切应力、压缩和静水压力等机械因素表现出显著的敏感性,这些因素决定了它们的激活、分化和功能极化。单核细胞由骨髓发育而来,遍布全身的脉管系统。在炎症期间,它们通过趋化因子和促炎细胞因子被招募到受伤或病变组织,通过机械感应和机械转导途径调节胚胎发育和成年期的局部免疫反应。本文综述了单核细胞力学生物学的最新进展。它强调了骨髓ECM机制如何协调骨髓形成,内皮细胞和血流动力学力量在迁移中的作用,以及组织力学如何影响慢性炎症、纤维化和癌症中的单核细胞命运。我们讨论了在健康和疾病中控制单核细胞行为的机械敏感途径,以及通过生物材料方法针对这些机制产生的治疗机会。此外,还讨论了未来发展免疫调节机械疗法的方向。通过连接机械生物学和免疫学,本综述强调了机械线索作为重编程疾病中单核细胞行为的治疗靶点的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
APL Bioengineering
APL Bioengineering ENGINEERING, BIOMEDICAL-
CiteScore
9.30
自引率
6.70%
发文量
39
审稿时长
19 weeks
期刊介绍: APL Bioengineering is devoted to research at the intersection of biology, physics, and engineering. The journal publishes high-impact manuscripts specific to the understanding and advancement of physics and engineering of biological systems. APL Bioengineering is the new home for the bioengineering and biomedical research communities. APL Bioengineering publishes original research articles, reviews, and perspectives. Topical coverage includes: -Biofabrication and Bioprinting -Biomedical Materials, Sensors, and Imaging -Engineered Living Systems -Cell and Tissue Engineering -Regenerative Medicine -Molecular, Cell, and Tissue Biomechanics -Systems Biology and Computational Biology
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