[Prognostic value of serum CD4⁺ and NK cells for the treatment response in children with aplastic anemia].

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-06-15 DOI:10.7499/j.issn.1008-8830.2410063

Chun-Can Wu, Mei Yan, Hailiguli Nuriddin, Xu-Kai Ma, Yu Liu

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引用次数: 0

Abstract

Objectives: To evaluate the clinical value of CD4⁺ cell percentage (CD4⁺%) and NK cell percentage (NK%) in predicting treatment outcomes in children with aplastic anemia (AA), providing a reference for precise diagnosis and treatment.

Methods: This retrospective study analyzed the clinical data of AA children treated with cyclosporine A at the First Affiliated Hospital of Xinjiang Medical University from January 2019 to April 2024. The study involved 48 AA children as the observation group and 50 children undergoing medical check-ups during the same period as the control group. Lymphocyte subset data were collected from both groups to analyze differences and their relationship with treatment efficacy. Based on hematological responses, the observation group was divided into an effective group of 18 patients (HR group, including complete and partial remission) and an ineffective group of 30 patients (NHR group, including non-remission).

Results: Univariate analysis showed that NK% in the observation group was significantly lower than that in the control group (P<0.05). The observation group was followed up for 3 months. The HR group had a lower CD4⁺% than the NHR group (P=0.018) and a higher NK% than the NHR group (P=0.029). Multivariate logistic regression analysis indicated that a high CD4⁺% was a risk factor for poor treatment efficacy (OR=1.062), whereas a high NK% was a protective factor (OR=0.820). The area under the curve for the prediction of HR in pediatric AA by combining CD4⁺% and NK% was 0.812.

Conclusions: A higher CD4⁺% at diagnosis is a predictor of poor treatment response, whereas a higher NK% is associated with better outcomes.

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[血清CD4+和NK细胞对再生障碍性贫血患儿治疗反应的预后价值]。

目的：评价CD4 +细胞百分率（CD4 + %）和NK +细胞百分率（NK%）在预测再生障碍性贫血（AA）患儿治疗结果中的临床价值，为精准诊断和治疗提供参考。方法：回顾性分析2019年1月至2024年4月新疆医科大学第一附属医院AA患儿应用环孢素A治疗的临床资料。本研究以48名AA儿童为观察组，50名同期接受体检的儿童为对照组。收集两组淋巴细胞亚群数据，分析差异及其与治疗效果的关系。根据血液学反应将观察组分为有效组18例（HR组，包括完全缓解和部分缓解）和无效组30例（NHR组，包括未缓解）。结果：单因素分析显示，观察组NK%显著低于对照组（PP=0.018），显著高于NHR组（P=0.029）。多因素logistic回归分析显示，CD4 + %高是治疗效果差的危险因素（OR=1.062）， NK%高是治疗效果差的保护因素（OR=0.820）。结合CD4 + %和NK%预测儿童AA HR的曲线下面积为0.812。结论：诊断时较高的CD4 + %是治疗反应较差的预测因子，而较高的NK%与较好的结果相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.