[Multicenter study on etiological characteristics of bacterial meningitis in infants aged < 90 days].

Q3 Medicine

中国当代儿科杂志 Pub Date : 2025-06-15 DOI:10.7499/j.issn.1008-8830.2412038

Ying Liu, Xue Feng, Jin Gao, Ying Xiong, Chang Liu, Xin-Lin Hou

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引用次数: 0

Abstract

Objectives: To investigate the etiological characteristics of bacterial meningitis (BM) in infants aged <90 days.

Methods: A retrospective analysis was conducted on the etiology and outcomes of BM in infants aged <90 days admitted to five collaborating hospitals between January 2007 and December 2021. The overall etiological profile was described, and pathogen distributions were compared across different age groups, regions, and years. The prognosis of BM caused by common pathogens was also evaluated.

Results: A total of 197 infants with bacteriologically confirmed BM were included. The most common pathogens were Escherichia coli (E. coli) (72 cases, 36.5%), group B Streptococcus (GBS) (49 cases, 24.9%), and Listeria monocytogenes (LM) (11 cases, 5.6%). The detection rate of E. coli was significantly higher in the neonatal group than in the infant group (40.2% vs 18.2%, P<0.05). E. coli was the predominant pathogen in Beijing (31.7%) and Kunming (54.1%), while GBS and E. coli were equally prevalent in Shenzhen (33.3%). From 2018 to 2021, the detection rates of E. coli were 46.4%, 47.2%, 45.2%, and 36.8%, respectively, whereas those of GBS were 25.0%, 27.8%, 22.6%, and 31.6%. No significant difference was observed in the overall complication rates among BM cases caused by E. coli, GBS, and LM (P>0.05). However, ventriculitis and hydrocephalus were more frequent in LM meningitis than in GBS meningitis (P<0.017).

Conclusions: E. coli is the most common pathogen in BM among young infants, particularly neonates. GBS is predominant in Shenzhen, with an increasing trend. LM meningitis accounts for a notable proportion of cases and is associated with poorer outcomes.

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[90天以下婴幼儿细菌性脑膜炎病因学特征的多中心研究]。

目的：探讨老年婴幼儿细菌性脑膜炎（BM）的病因学特点。方法：回顾性分析老年婴幼儿BM的病因学及转归。结果：共纳入细菌学证实的BM患儿197例。最常见的病原菌为大肠杆菌（E. coli） 72例（36.5%）、B群链球菌（GBS） 49例（24.9%）、单核增生李斯特菌（LM） 11例（5.6%）。新生儿组大肠杆菌检出率明显高于婴儿组（40.2% vs 18.2%, p < 0.05）。然而，脑室炎和脑积水在LM脑膜炎中比在GBS脑膜炎中更常见。结论：大肠杆菌是年幼婴儿，尤其是新生儿中最常见的BM病原体。深圳以GBS为主，且呈上升趋势。LM脑膜炎占病例的显著比例，并与较差的预后相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国当代儿科杂志 Medicine-Pediatrics, Perinatology and Child Health

CiteScore

1.50

自引率

0.00%

发文量

5006

期刊介绍： The Chinese Journal of Contemporary Pediatrics (CJCP) is a peer-reviewed open access periodical in the field of pediatrics that is sponsored by the Central South University/Xiangya Hospital of Central South University and under the auspices of the Ministry of Education of China. It is cited as a source in the scientific and technological papers of Chinese journals, the Chinese Science Citation Database (CSCD), and is one of the core Chinese periodicals in the Peking University Library. CJCP has been indexed by MEDLINE/PubMed/PMC of the American National Library, American Chemical Abstracts (CA), Holland Medical Abstracts (EM), Western Pacific Region Index Medicus (WPRIM), Scopus and EBSCO. It is a monthly periodical published on the 15th of every month, and is distributed both at home and overseas. The Chinese series publication number is CN 43-1301/R；ISSN 1008-8830. The tenet of CJCP is to “reflect the latest advances and be open to the world”. The periodical reports the most recent advances in the contemporary pediatric field. The majority of the readership is pediatric doctors and researchers.