Devish Pyakurel, Keyoor Gautam, Robin Bahadur Basnet, Vivek Pant
{"title":"Comprehensive Analysis of Renal Stones Using FTIR Spectroscopy in a Referral Laboratory in Nepal.","authors":"Devish Pyakurel, Keyoor Gautam, Robin Bahadur Basnet, Vivek Pant","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Renal stone disease, a prevalent urological disorder, significantly impacts public health in Nepal. Analyzing the composition of renal stones is crucial for understanding their etiology and guiding treatment and prevention strategies. FTIR spectroscopy is a reliable technique for identifying the chemical composition of renal stones. This study aims to analyze the composition of renal stones using FTIR spectroscopy in a referral laboratory in Nepal.</p><p><strong>Methods: </strong>A total of 300 renal stones from patients were analyzed. The stones were collected, cleaned, and powdered before being subjected to the Thermo Fisher Scientific FTIR Spectrometer. The spectra obtained were compared to the reference spectra to determine the composition of the stones.</p><p><strong>Results: </strong>The analysis revealed that calcium oxalate monohydrate in 41% and calcium oxalate dihydrate in 29 % were the commonest types. Other less common compositions included uric acid, struvite, and cystine stones.</p><p><strong>Conclusion: </strong>FTIR spectroscopy effectively identified the composition of renal stones in the studied population. The predominance of calcium oxalate stone highlights the need for targeted prevention and treatment strategies in Nepal.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"36 2","pages":"177-186"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205142/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
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Abstract
Background: Renal stone disease, a prevalent urological disorder, significantly impacts public health in Nepal. Analyzing the composition of renal stones is crucial for understanding their etiology and guiding treatment and prevention strategies. FTIR spectroscopy is a reliable technique for identifying the chemical composition of renal stones. This study aims to analyze the composition of renal stones using FTIR spectroscopy in a referral laboratory in Nepal.
Methods: A total of 300 renal stones from patients were analyzed. The stones were collected, cleaned, and powdered before being subjected to the Thermo Fisher Scientific FTIR Spectrometer. The spectra obtained were compared to the reference spectra to determine the composition of the stones.
Results: The analysis revealed that calcium oxalate monohydrate in 41% and calcium oxalate dihydrate in 29 % were the commonest types. Other less common compositions included uric acid, struvite, and cystine stones.
Conclusion: FTIR spectroscopy effectively identified the composition of renal stones in the studied population. The predominance of calcium oxalate stone highlights the need for targeted prevention and treatment strategies in Nepal.
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