{"title":"Changing paradigms in evaluating adrenal incidentalomas: Bayesian evaluation of [<sup>18</sup>F]Fluorodeoxyglucose positron emission tomography use, honed on adrenocortical carcinoma.","authors":"Ioannis Ilias, Georgios Meristoudis","doi":"10.5306/wjco.v16.i6.106511","DOIUrl":null,"url":null,"abstract":"<p><p>We present the diagnostic performance of [<sup>18</sup>F]Fluorodeoxyglucose positron emission tomography (FDG PET) for adrenal incidentalomas based on lesion size and unenhanced computed tomography (CT) density in Hounsfield units (HU), following current literature and guidelines. A 20 HU cutoff can be applied to differentiate potentially benign from malignant lesions, particularly in ruling in or out adrenocortical carcinoma. While FDG PET provides valuable metabolic information, its likelihood ratios for a positive (LR+) or negative (LR-) result do not exceed the robust diagnostic thresholds of > 10.0 or < 0.1, respectively. This suggests that positron emission tomography alone is insufficient for definitive characterization and should be integrated with CT or magnetic resonance imaging to leverage their complementary anatomical and functional imaging strengths for optimal diagnostic accuracy.</p>","PeriodicalId":23802,"journal":{"name":"World journal of clinical oncology","volume":"16 6","pages":"106511"},"PeriodicalIF":3.2000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198865/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of clinical oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5306/wjco.v16.i6.106511","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
We present the diagnostic performance of [18F]Fluorodeoxyglucose positron emission tomography (FDG PET) for adrenal incidentalomas based on lesion size and unenhanced computed tomography (CT) density in Hounsfield units (HU), following current literature and guidelines. A 20 HU cutoff can be applied to differentiate potentially benign from malignant lesions, particularly in ruling in or out adrenocortical carcinoma. While FDG PET provides valuable metabolic information, its likelihood ratios for a positive (LR+) or negative (LR-) result do not exceed the robust diagnostic thresholds of > 10.0 or < 0.1, respectively. This suggests that positron emission tomography alone is insufficient for definitive characterization and should be integrated with CT or magnetic resonance imaging to leverage their complementary anatomical and functional imaging strengths for optimal diagnostic accuracy.
期刊介绍：
The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.
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