Regulation of matrix metalloproteinase-13 in cancer: Signaling pathways and non-coding RNAs in tumor progression and therapeutic targeting.

IF 3.2 Q3 ONCOLOGY

World journal of clinical oncology Pub Date : 2025-06-24 DOI:10.5306/wjco.v16.i6.105996

Deekshaa Chidambaram, Velan Subashini, Muthuvairaprasath Nanthanalaxmi, Iyyappan Saranya, Nagarajan Selvamurugan

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引用次数: 0

Abstract

Matrix metalloproteinases (MMPs) are essential enzymes involved in extracellular matrix degradation and remodeling. Such processes are integral to normal tissue homeostasis and several pathological conditions such as cancer. Among these MMPs, MMP-13 plays a key role in cancer progression, driving tumor invasion, metastasis, and angiogenesis. Despite significant advancements in understanding its biology, therapeutic targeting of MMP-13 remains challenging owing to its complex and multifaceted regulatory mechanisms. Recent studies have underscored the pivotal role of non-coding RNAs (ncRNAs), including long ncRNAs, microRNAs, and circular RNAs, in modulating MMP-13 expression. This review provides a comprehensive analysis of MMP-13 regulation by several signaling pathways, the influence of ncRNAs on these signaling pathways, and MMP-13 expression during cancer progression and metastasis. Furthermore, we explored the clinical relevance of ncRNA-mediated regulatory networks, highlighting their potential as diagnostic biomarkers and therapeutic targets in various cancers. By unraveling these regulatory mechanisms, this review offers valuable insights into innovative strategies for cancer diagnosis and treatment and emphasizes the translational significance of ncRNA-mediated MMP-13 regulation in oncology.

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基质金属蛋白酶-13在癌症中的调控：肿瘤进展和治疗靶向中的信号通路和非编码rna。

基质金属蛋白酶（MMPs）是参与细胞外基质降解和重塑的重要酶。这些过程是正常组织稳态和一些病理条件（如癌症）所必需的。在这些MMPs中，MMP-13在癌症进展、驱动肿瘤侵袭、转移和血管生成中起关键作用。尽管在了解其生物学方面取得了重大进展，但由于其复杂和多方面的调节机制，MMP-13的治疗靶向仍然具有挑战性。最近的研究强调了非编码rna （ncRNAs）在调节MMP-13表达中的关键作用，包括长链ncRNAs、微rna和环状rna。本文综述了几种信号通路对MMP-13的调控，ncrna对这些信号通路的影响，以及MMP-13在癌症进展和转移过程中的表达。此外，我们探讨了ncrna介导的调控网络的临床相关性，强调了它们作为各种癌症的诊断生物标志物和治疗靶点的潜力。通过揭示这些调控机制，本综述为癌症诊断和治疗的创新策略提供了有价值的见解，并强调了ncrna介导的MMP-13调控在肿瘤学中的翻译意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World journal of clinical oncology ONCOLOGY-

自引率

0.00%

发文量

585

期刊介绍： The WJCO is a high-quality, peer reviewed, open-access journal. The primary task of WJCO is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of oncology. In order to promote productive academic communication, the peer review process for the WJCO is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJCO are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in oncology. Scope: Art of Oncology, Biology of Neoplasia, Breast Cancer, Cancer Prevention and Control, Cancer-Related Complications, Diagnosis in Oncology, Gastrointestinal Cancer, Genetic Testing For Cancer, Gynecologic Cancer, Head and Neck Cancer, Hematologic Malignancy, Lung Cancer, Melanoma, Molecular Oncology, Neurooncology, Palliative and Supportive Care, Pediatric Oncology, Surgical Oncology, Translational Oncology, and Urologic Oncology.