Histological response and blood glucose level in a diabetic animal model after the oral administration of Mucuna pruriens: A systematic review and meta-analysis.

IF 2 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE
Veterinary World Pub Date : 2025-05-01 Epub Date: 2025-05-31 DOI:10.14202/vetworld.2025.1377-1388
Tri Wahyu Pangestiningsih, Dian Meididewi Nuraini, Morsid Andityas, Ariana Ariana
{"title":"Histological response and blood glucose level in a diabetic animal model after the oral administration of <i>Mucuna pruriens</i>: A systematic review and meta-analysis.","authors":"Tri Wahyu Pangestiningsih, Dian Meididewi Nuraini, Morsid Andityas, Ariana Ariana","doi":"10.14202/vetworld.2025.1377-1388","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and aim: </strong><i>Mucuna pruriens</i> (MP) has emerged as a promising natural antidiabetic agent due to its rich bioactive composition. Although numerous preclinical studies have reported its hypoglycemic and histological benefits, a comprehensive synthesis quantifying these effects has been lacking. This study systematically evaluated the dual impact of orally administered MP extract on histopathological changes and blood glucose levels in diabetic animal models through a systematic review and meta-analysis.</p><p><strong>Material and methods: </strong>A systematic literature search was conducted across four databases (PubMed, Scopus, ScienceDirect, and Google Scholar) without date restrictions. Eligible <i>in vivo</i> studies were selected based on predefined inclusion criteria, and data were extracted following PRISMA guidelines. Risk of bias was assessed using the systematic review center for laboratory animal experimentation tools. Histological outcomes were summarized descriptively, while blood glucose levels were analyzed quantitatively using a random-effects meta-analysis. Subgroup analyses were performed based on MP concentration, duration of administration, and plant part used.</p><p><strong>Results: </strong>Sixteen studies were included, with 13 eligible for meta-analysis. MP extract significantly reduced blood glucose levels, with an overall standardized mean difference of -18.36 (95% confidence intervals: -21.22, -15.51; p < 0.01). Subgroup analyses revealed that lower MP doses (≤100 mg/kg) achieved superior glycemic control with prolonged administration (>4 weeks), whereas higher doses (≥200 mg/kg) were most effective within 1-4 weeks. Histological analysis indicated regenerative effects of MP on the pancreas, liver, pituitary gland, and corpus cavernosum. Seed extracts exhibited a stronger hypoglycemic effect compared to leaf extracts. Potential publication bias was detected but was addressed through trim-and-fill analysis.</p><p><strong>Conclusion: </strong>MP extract demonstrates significant antidiabetic potential through glycemic regulation and organ tissue restoration. Lower concentrations are preferable for long-term administration, while higher concentrations are optimal for short-term therapy. The findings advocate MP as a valuable candidate for integrative diabetes management strategies. Further clinical studies are recommended to validate its translational potential.</p>","PeriodicalId":23587,"journal":{"name":"Veterinary World","volume":"18 5","pages":"1377-1388"},"PeriodicalIF":2.0000,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205235/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary World","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14202/vetworld.2025.1377-1388","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/31 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}
引用次数: 0

Abstract

Background and aim: Mucuna pruriens (MP) has emerged as a promising natural antidiabetic agent due to its rich bioactive composition. Although numerous preclinical studies have reported its hypoglycemic and histological benefits, a comprehensive synthesis quantifying these effects has been lacking. This study systematically evaluated the dual impact of orally administered MP extract on histopathological changes and blood glucose levels in diabetic animal models through a systematic review and meta-analysis.

Material and methods: A systematic literature search was conducted across four databases (PubMed, Scopus, ScienceDirect, and Google Scholar) without date restrictions. Eligible in vivo studies were selected based on predefined inclusion criteria, and data were extracted following PRISMA guidelines. Risk of bias was assessed using the systematic review center for laboratory animal experimentation tools. Histological outcomes were summarized descriptively, while blood glucose levels were analyzed quantitatively using a random-effects meta-analysis. Subgroup analyses were performed based on MP concentration, duration of administration, and plant part used.

Results: Sixteen studies were included, with 13 eligible for meta-analysis. MP extract significantly reduced blood glucose levels, with an overall standardized mean difference of -18.36 (95% confidence intervals: -21.22, -15.51; p < 0.01). Subgroup analyses revealed that lower MP doses (≤100 mg/kg) achieved superior glycemic control with prolonged administration (>4 weeks), whereas higher doses (≥200 mg/kg) were most effective within 1-4 weeks. Histological analysis indicated regenerative effects of MP on the pancreas, liver, pituitary gland, and corpus cavernosum. Seed extracts exhibited a stronger hypoglycemic effect compared to leaf extracts. Potential publication bias was detected but was addressed through trim-and-fill analysis.

Conclusion: MP extract demonstrates significant antidiabetic potential through glycemic regulation and organ tissue restoration. Lower concentrations are preferable for long-term administration, while higher concentrations are optimal for short-term therapy. The findings advocate MP as a valuable candidate for integrative diabetes management strategies. Further clinical studies are recommended to validate its translational potential.

口服麻粪草后糖尿病动物模型的组织学反应和血糖水平:一项系统回顾和荟萃分析。
背景与目的:麝香草(Mucuna pruriens, MP)因其丰富的生物活性成分而成为一种很有前景的天然降糖药。尽管许多临床前研究已经报道了它的降糖和组织学益处,但缺乏对这些作用进行全面量化的综合研究。本研究通过系统综述和荟萃分析,系统评估了口服MP提取物对糖尿病动物模型的组织病理学改变和血糖水平的双重影响。材料和方法:在四个数据库(PubMed、Scopus、ScienceDirect和谷歌Scholar)中进行了系统的文献检索,没有日期限制。根据预先确定的纳入标准选择符合条件的体内研究,并按照PRISMA指南提取数据。使用实验动物实验工具系统评价中心评估偏倚风险。对组织学结果进行描述性总结,同时使用随机效应荟萃分析对血糖水平进行定量分析。亚组分析基于MP浓度、给药时间和使用的植物部位。结果:纳入16项研究,其中13项符合meta分析。MP提取物显著降低血糖水平,总体标准化平均差值为-18.36(95%置信区间:-21.22,-15.51;P < 0.01)。亚组分析显示,低剂量MP(≤100mg /kg)在延长给药时间(bbb4周)后达到了较好的血糖控制效果,而高剂量MP(≥200mg /kg)在1-4周内最有效。组织学分析表明,MP对胰腺、肝脏、脑垂体和海绵体有再生作用。与叶片提取物相比,种子提取物表现出更强的降糖作用。发现了潜在的发表偏倚,但通过补齐分析加以解决。结论:MP提取物具有明显的降糖作用,具有调节血糖和恢复器官组织功能的作用。较低的浓度适合长期使用,而较高的浓度适合短期治疗。研究结果提倡MP作为综合糖尿病管理策略的有价值的候选人。建议进一步的临床研究来验证其转化潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Veterinary World
Veterinary World Multiple-
CiteScore
3.60
自引率
12.50%
发文量
317
审稿时长
16 weeks
期刊介绍: Veterinary World publishes high quality papers focusing on Veterinary and Animal Science. The fields of study are bacteriology, parasitology, pathology, virology, immunology, mycology, public health, biotechnology, meat science, fish diseases, nutrition, gynecology, genetics, wildlife, laboratory animals, animal models of human infections, prion diseases and epidemiology. Studies on zoonotic and emerging infections are highly appreciated. Review articles are highly appreciated. All articles published by Veterinary World are made freely and permanently accessible online. All articles to Veterinary World are posted online immediately as they are ready for publication.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信