A 15-year study of neuraminidase mutations and the increasing of S247N mutation in Spain

IF 2.7 4区 医学 Q3 VIROLOGY
Iván Sanz-Muñoz , Alejandro Martín-Toribio , Adrián García-Concejo , Irene Arroyo-Hernantes , Marina Toquero-Asensio , Javier Sánchez-Martínez , Carla Rodríguez-Crespo , Silvia Rojo-Rello , Marta Domínguez-Gil , Eduardo Tamayo-Gómez , Marta Hernández-Pérez , José M Eiros
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引用次数: 0

Abstract

The therapeutic arsenal against influenza is extremely limited and resistance often arises due to the emergence of mutations, especially in the neuraminidase (NA) gene. This study aimed to evaluate the evolution of NA mutations over 15 years in Spain. To do so, we used the GISAID database from which we downloaded a total of 11,125 influenza A(H1N1)pdm09, A(H3N2), B/Victoria and B/Yamagata NA virus sequences, and analyzed the resistance mutations using FluSurver software. Our results showed that the occurrence of NA resistance mutations remained constant in the four viruses during the 15 seasons evaluated, being around 0.5–5 %. Most of the resistance was found in the A(H1N1)pdm09 subtype (around 70 %), especially from the 2023–2024 season onwards, when a significant increase in the occurrence of S247N mutation was observed. The occurrence of this type of mutation before 2022 was rare, but in the 2023–2024 season a total of 44 influenza viruses harboring S247N mutations were detected, while in the other years, only two cases were observed. Some studies have described a significant increase in this mutation over the past two seasons and although it appears to confer only slightly reduced inhibition to oseltamivir, its increase is noteworthy and should be a reason for increased their vigilance.
西班牙神经氨酸酶突变和S247N突变增加的15年研究
针对流感的治疗武器库极其有限,并且由于突变的出现,特别是在神经氨酸酶(NA)基因中,经常出现耐药性。本研究旨在评估15年来西班牙NA突变的演变。为此,我们利用GISAID数据库下载了共11125个甲型H1N1流感病毒pdm09、a (H3N2)、B/Victoria和B/Yamagata NA病毒序列,并使用FluSurver软件分析了抗性突变。结果表明,在15个季节中,4种病毒的NA抗性突变发生率保持不变,约为0.5-5%。大多数耐药发生在甲型H1N1 pdm09亚型(约70%),特别是从2023-2024年季节开始,观察到S247N突变的发生显著增加。在2022年之前,这种类型的突变很少发生,但在2023-2024年流感季节,共检测到44例携带S247N突变的流感病毒,而在其他年份,仅观察到2例。一些研究描述了在过去两个季节中这种突变的显著增加,尽管它似乎只使奥司他韦的抑制作用略有降低,但它的增加是值得注意的,应该是提高警惕的一个原因。
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来源期刊
Virus research
Virus research 医学-病毒学
CiteScore
9.50
自引率
2.00%
发文量
239
审稿时长
43 days
期刊介绍: Virus Research provides a means of fast publication for original papers on fundamental research in virology. Contributions on new developments concerning virus structure, replication, pathogenesis and evolution are encouraged. These include reports describing virus morphology, the function and antigenic analysis of virus structural components, virus genome structure and expression, analysis on virus replication processes, virus evolution in connection with antiviral interventions, effects of viruses on their host cells, particularly on the immune system, and the pathogenesis of virus infections, including oncogene activation and transduction.
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