Diagnostic quantitative thresholds for REM sleep without atonia in Japanese patients with isolated REM sleep behavior disorder.

IF 4.9 2区医学 Q1 Medicine

Sleep Pub Date : 2025-06-30 DOI:10.1093/sleep/zsaf178

Taeko Sakuma, Yoshino Kanai, Yoichiro Takei, Momoko Kimura, Yuichi Inoue

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引用次数: 0

Abstract

Study objectives: This study aims to clarify the diagnostic cutoff values of REM sleep without atonia (RWA) for identifying isolated RBD (iRBD) in Japanese population. We will analyze these cutoff values according to the established methods and explore their validity with clinical and neurophysiological markers.

Methods: We analyzed RWA in 79 patients with clinical iRBD and 59 age-, sex-, PLMS- apnea-hypopnea index-matched controls. Cutoff values for diagnosing iRBD for phasic RWA in the SM and limbs, tonic RWA in the SM, and a combination of any RWA in the SM and phasic RWA in the FDS were calculated. In patients with iRBD, clinical and neurophysiological markers were compared between groups categorized by the existing cutoff level and the newly defined level in this study.

Results: Optimized and maximized specificity diagnostic cutoffs for iRBD were: 9.4 and 15.6% in phasic RWA in the SM and limbs (AUC = 0.992), 0.94% and 11.9% in tonic RWA in SM (AUC = 0.912), and 11.3% and 11.3% in combination of any RWA in the SM and phasic RWA in the FDS (AUC = 0.973). Clinical and neurophysiological markers were mostly not different between the groups categorized by the previous and current cutoff values.

Conclusions: A lower RWA cutoff for diagnosing iRBD was identified in Japanese individuals compared to Western populations, though the clinical significance of this difference was minimal.

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日本孤立性快速眼动睡眠行为障碍患者无张力快速眼动睡眠的诊断定量阈值。

研究目的：本研究旨在阐明日本人群中无张力快速眼动睡眠（RWA）对孤立性RBD （iRBD）的诊断截止值。我们将根据已建立的方法分析这些截止值，并探讨其与临床和神经生理标志物的有效性。方法：我们分析了79例临床iRBD患者和59例年龄、性别、PLMS-呼吸暂停低通气指数匹配的对照组的RWA。计算了SM和四肢的相位RWA、SM的强直RWA以及SM的任意RWA和FDS的相位RWA的组合诊断iRBD的截止值。在iRBD患者中，将临床和神经生理标志物在本研究中按现有截止水平和新定义水平分类的组之间进行比较。结果：优化和最大化的iRBD特异性诊断临界值分别为：SM和四肢的相位RWA分别为9.4和15.6% (AUC = 0.992)， SM的强直RWA分别为0.94%和11.9% (AUC = 0.912)， SM的任意RWA和FDS的相位RWA的联合诊断临界值分别为11.3%和11.3% （AUC = 0.973）。临床和神经生理指标在以前和现在的截止值分类的组之间大多没有差异。结论：与西方人群相比，日本个体诊断iRBD的RWA截止值较低，尽管这种差异的临床意义很小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep Medicine-Neurology (clinical)

CiteScore

8.70

自引率

10.70%

发文量

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