What's new in the assessment of lupus activity?

IF 2.1 Q3 RHEUMATOLOGY

Rheumatology Advances in Practice Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI:10.1093/rap/rkaf062

Ana Isabel Ramos-Lisbona, Nur Azizah Allameen, David A Isenberg

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Abstract

Capturing disease activity in SLE remains challenging. The binary nature of global score indices such as the SLEDAI 2000 (SLEDAI-2K) poses limitations, while the complexity of the BILAG-2004 index requires training and more time investment. Recent efforts to improve SLE activity indices include the SLE Disease Activity Score (SLE-DAS) and Easy-BILAG system. This review analyses the main indices used to assess SLE activity, examines their progressive refinements, evaluates their advantages and limitations and aims to identify the optimal index. The SLE-DAS offers greater sensitivity than the SLEDAI-2K and the Easy-BILAG simplifies scoring while maintaining the comprehensiveness of the BILAG-2004. Composite indices like the SLE Responder Index and BILAG-based Composite Lupus Assessment integrate the SLEDAI-2K and BILAG-2004 but are mainly used in clinical trials due to their complexity. This review emphasizes the importance of balancing sensitivity, specificity, simplicity and comprehensiveness in lupus activity measurement. The search for the optimal index remains ongoing.

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狼疮活动评估有什么新进展？

捕获SLE的疾病活动性仍然具有挑战性。全球得分指数如SLEDAI 2000 （SLEDAI- 2k）的二元性存在局限性，而BILAG-2004指数的复杂性需要培训和更多的时间投入。最近改善SLE活动性指标的努力包括SLE疾病活动性评分（SLE- das）和Easy-BILAG系统。本文分析了用于评估SLE活动性的主要指标，考察了它们的逐步改进，评估了它们的优点和局限性，旨在确定最佳指标。sleda - das提供了比SLEDAI-2K和Easy-BILAG更大的灵敏度，简化了评分，同时保持了BILAG-2004的全面性。SLE应答者指数和基于bilag的狼疮综合评估等综合指标整合了SLEDAI-2K和BILAG-2004，但由于其复杂性，主要用于临床试验。这篇综述强调了平衡敏感性、特异性、简单性和全面性在狼疮活动测量中的重要性。寻找最优指数的工作仍在继续。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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