Impact of obesity on metabolic control in type 2 diabetes: Five-year trends of Turkish nationwide survEy of glycemic and other Metabolic parameters of patients with Diabetes (TEMD Obesity Study, 2017-2022).
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引用次数: 0
Abstract
Background: Türkiye has the highest obesity prevalence in Europe. Obesity not only causes type 2 diabetes mellitus (T2DM) but also impairs glycemic control in patients with T2DM. There is insufficient information about the demographic and clinical differences between individuals with T2DM who are living with or without obesity.
Objectives: The second TEMD survey across Türkiye investigated the latest overweight and obesity prevalence in patients with T2DM. The present study evaluated the five-year changes in the prevalence, factors associated with an obesity diagnosis and the association between obesity and metabolic control.
Methods: Patients under follow-up in tertiary units specialized for diabetes care were consecutively enrolled. The sociodemographic, anthropometric, and clinical variables were recorded. Metabolic targets were defined as HbA1c <7%, home arterial blood pressure (ABP)<135/85 mmHg, or LDL-C<100 mg/dL or <70 mg/dL or <55 mg/dL according to the risk factors or complications of patients. Metabolic target attainment rates were investigated across normal-weight, overweight and obesity body mass index (BMI) classes.
Results: The TEMD Obesity Study enrolled 4935 patients with T2DM (age 58.9±10.1 years; women 59.8%). The prevalence of overweight and obesity was 33.4% and 55.1%, respectively. Obesity was more frequent in women with T2DM than men (66.2% vs. 38.1%; p=<0.001). From 2017 to 2022, the obesity rate decreased from 59.0% to 55.1%, while the overweight rate increased from 31.0% to 33.4%. As BMI class increased, the achievement of three metabolic targets decreased while the incidence of microvascular complications rose. Significant associations were found between obesity and sociodemographic characteristics (age, sex, education level) and lifestyle measures (diet, exercise, smoking) in multivariable logistic regression analysis.
Conclusion: The TEMD Obesity study showed a decrease in obesity rates among patients with T2DM between 2017 and 2022. Also, the findings suggest that obesity poses an important barrier to the achievement of metabolic goals. .
背景：土耳其是欧洲肥胖患病率最高的国家。肥胖不仅会导致2型糖尿病（T2DM），而且会损害T2DM患者的血糖控制。关于伴有或不伴有肥胖的2型糖尿病患者的人口学和临床差异的信息不足。目的：在全国范围内进行的第二次TEMD调查调查了T2DM患者中最新的超重和肥胖患病率。本研究评估了患病率的五年变化，与肥胖诊断相关的因素以及肥胖与代谢控制之间的关系。方法：连续入组在三级糖尿病专科医院接受随访的患者。记录社会人口学、人体测量学和临床变量。结果：TEMD肥胖研究纳入了4935例T2DM患者(年龄58.9±10.1岁；女性59.8%)。超重和肥胖患病率分别为33.4%和55.1%。女性2型糖尿病患者的肥胖发生率高于男性(66.2% vs. 38.1%；结论：TEMD肥胖研究显示，2017年至2022年期间，T2DM患者的肥胖率有所下降。此外，研究结果表明，肥胖是实现代谢目标的一个重要障碍。。
期刊介绍：
''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.
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