The Effect of Omega-3 Supplements on Renal Function Indices in Chronic Kidney Patients Undergoing Hemodialysis.

IF 2.3 Q3 NUTRITION & DIETETICS

Nutrition and Metabolic Insights Pub Date : 2025-06-27 eCollection Date: 2025-01-01 DOI:10.1177/11786388251345518

Mobina Zeinalabedini, Mahsa Shapouri, Pouya Mirzaee, Majid Kamali, Zahra Mahmoudi, Narjes Noriani, Zahra Saeedirad, Somayyeh Bararnia Adabi, Khadijeh Abbasi Mobarakeh, Ali Shamsi-Goushki, Hanieh Shafaei, Barbod Alhouei, Saeid Doaei, Masoud Khosravi, Maryam Gholamalizadeh

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引用次数: 0

Abstract

Background: Recent studies reported that omega-3 fatty acids may improve renal function in patients with chronic kidney disease (CKD). The aim of the present study was to assess the effect of omega-3 supplements on renal function indices in patients with CKD undergoing hemodialysis.

Methods: This randomized controlled clinical trial was carried out on 120 CKD patients who were undergoing hemodialysis treatment in Rasht, Iran. The intervention group (n = 60) received 3 capsules of 1000 mg omega-3 fatty acid supplement capsules daily for 2 months. The control group (n = 60) received 3 placebo capsules containing 1000 mg of MCT. Renal function indicators included blood urea nitrogen (BUN), creatinine (Cr), sodium (Na), potassium (K), calcium (Ca), and phosphorus (P) were measured at baseline and after the intervention.

Results: Omega-3 supplementation significantly improved BUN (68.26 ± 2.97 to 56.59 ± 2.14, P = .03) and Cr levels (8.94 ± 0.29 to 7.58 ± 0.41, P < .01) after adjustment for age, gender, body mass index (BMI), smoking, diet, and underlying diseases including diabetes and hypertension. However, no significant effect was found on serum levels of Na, K, Ca, and P.

Conclusion: According to the present study, giving omega-3 supplementation to patients with CKD undergoing HD may enhanced their renal function. Additional research is required to verify these results.

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Omega-3补充剂对血液透析慢性肾病患者肾功能指标的影响。

背景：最近的研究报道，omega-3脂肪酸可以改善慢性肾脏疾病（CKD）患者的肾功能。本研究的目的是评估omega-3补充剂对接受血液透析的CKD患者肾功能指标的影响。方法：本随机对照临床试验在伊朗Rasht进行120例接受血液透析治疗的CKD患者。干预组（n = 60）每天服用3粒omega-3脂肪酸补充胶囊1000 mg，持续2个月。对照组（n = 60）给予3粒含有1000mg MCT的安慰剂胶囊。在基线和干预后测量肾功能指标包括血尿素氮（BUN）、肌酐（Cr）、钠（Na）、钾(K)、钙（Ca）、磷(P)。结果：补充Omega-3可显著改善BUN（68.26±2.97 ~ 56.59±2.14,P = 0.03）和Cr（8.94±0.29 ~ 7.58±0.41，P）水平。结论：根据本研究，CKD合并HD患者补充Omega-3可改善肾功能。需要进一步的研究来验证这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition and Metabolic Insights NUTRITION & DIETETICS-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.