Laryngeal non-Hodgkin lymphoma presenting as throat foreign body sensation: A case report.

IF 1.3 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Medicine Pub Date : 2025-06-27 DOI:10.1097/MD.0000000000043132

Hongming Liao, Ai He, Fengbo Yan, Benchao He

{"title":"Laryngeal non-Hodgkin lymphoma presenting as throat foreign body sensation: A case report.","authors":"Hongming Liao, Ai He, Fengbo Yan, Benchao He","doi":"10.1097/MD.0000000000043132","DOIUrl":null,"url":null,"abstract":"Rationale: Laryngeal lymphoma is an extremely rare malignancy, representing <1% of all laryngeal tumors. Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype. Due to its rarity and nonspecific symptoms, early diagnosis and timely treatment are critical.Patient concerns: A 67-year-old male presented with progressive hoarseness and a persistent sensation of a foreign body in the throat that had developed over several weeks.Diagnoses: Laryngoscopy revealed a submucosal mass involving the glottis. Contrast-enhanced computed tomography demonstrated soft tissue infiltration. Surgical excision was performed, and histopathological evaluation confirmed the diagnosis of diffuse large B-cell lymphoma of the larynx.Interventions: The patient received systemic chemotherapy tailored to the staging and anatomical location of the lymphoma, following current DLBCL treatment guidelines.Outcomes: The patient experienced significant symptom relief after chemotherapy, with resolution of hoarseness and foreign body sensation. No recurrence was observed during the 2-month follow-up period.Lessons: This case highlights the importance of considering lymphoma in the differential diagnosis of persistent hoarseness and throat discomfort. Early biopsy and multidisciplinary intervention are essential to achieve favorable outcomes in patients with rare laryngeal DLBCL.","PeriodicalId":18549,"journal":{"name":"Medicine","volume":"104 26","pages":"e43132"},"PeriodicalIF":1.3000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212830/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MD.0000000000043132","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Rationale: Laryngeal lymphoma is an extremely rare malignancy, representing <1% of all laryngeal tumors. Diffuse large B-cell lymphoma (DLBCL) is the most common histologic subtype. Due to its rarity and nonspecific symptoms, early diagnosis and timely treatment are critical.

Patient concerns: A 67-year-old male presented with progressive hoarseness and a persistent sensation of a foreign body in the throat that had developed over several weeks.

Diagnoses: Laryngoscopy revealed a submucosal mass involving the glottis. Contrast-enhanced computed tomography demonstrated soft tissue infiltration. Surgical excision was performed, and histopathological evaluation confirmed the diagnosis of diffuse large B-cell lymphoma of the larynx.

Interventions: The patient received systemic chemotherapy tailored to the staging and anatomical location of the lymphoma, following current DLBCL treatment guidelines.

Outcomes: The patient experienced significant symptom relief after chemotherapy, with resolution of hoarseness and foreign body sensation. No recurrence was observed during the 2-month follow-up period.

Lessons: This case highlights the importance of considering lymphoma in the differential diagnosis of persistent hoarseness and throat discomfort. Early biopsy and multidisciplinary intervention are essential to achieve favorable outcomes in patients with rare laryngeal DLBCL.

查看原文本刊更多论文

以喉部异物感为表现的喉部非霍奇金淋巴瘤1例。

理由：喉淋巴瘤是一种极其罕见的恶性肿瘤，代表了患者的关注：67岁男性，表现为进行性声音嘶哑，持续感觉喉咙内有异物，已发展数周。诊断：喉镜检查发现粘膜下肿块累及声门。增强计算机断层扫描显示软组织浸润。手术切除，组织病理学评估证实了喉部弥漫性大b细胞淋巴瘤的诊断。干预措施：患者接受了根据淋巴瘤分期和解剖位置量身定制的全身化疗，遵循目前的DLBCL治疗指南。结果：患者化疗后症状明显缓解，声音嘶哑、异物感消失。随访2个月无复发。本病例强调了在鉴别诊断持续性声音嘶哑和咽喉不适时考虑淋巴瘤的重要性。早期活检和多学科干预对于罕见的喉部DLBCL患者获得良好的预后至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

4342

审稿时长

>12 weeks

期刊介绍： Medicine is now a fully open access journal, providing authors with a distinctive new service offering continuous publication of original research across a broad spectrum of medical scientific disciplines and sub-specialties. As an open access title, Medicine will continue to provide authors with an established, trusted platform for the publication of their work. To ensure the ongoing quality of Medicine’s content, the peer-review process will only accept content that is scientifically, technically and ethically sound, and in compliance with standard reporting guidelines.