Understanding the rationale for metronidazole use in dogs and cats.

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice Pub Date : 2025-06-30 DOI:10.1111/jsap.13910

J Ng, N Steffensen, I Battersby, J S Weese, D Timofte, P L Toutain, J L Granick, J Elliott, S Choi, T Sparks, S Tavener, F Allerton

{"title":"Understanding the rationale for metronidazole use in dogs and cats.","authors":"J Ng, N Steffensen, I Battersby, J S Weese, D Timofte, P L Toutain, J L Granick, J Elliott, S Choi, T Sparks, S Tavener, F Allerton","doi":"10.1111/jsap.13910","DOIUrl":null,"url":null,"abstract":"Objective: It is currently unknown how often antibiotics (including metronidazole) are used for non-antibacterial purposes in dogs and cats. This study looked to characterise the rationale for metronidazole prescription in these species.Methods: Retrospective cohort study. Veterinarians reported clinical information for dogs and cats treated with metronidazole in the previous year, including the rationale for metronidazole selection.Results: Three hundred and thirty-two cases were reported by 138 veterinarians describing metronidazole use in 47 cats and 285 dogs. Metronidazole was most commonly prescribed to treat acute diarrhoea (n = 156, 47%), chronic diarrhoea (n = 79, 24%) or giardiasis (n = 36, 11%). Veterinarians selected metronidazole exclusively for non-antimicrobial targeted therapy in 42% of cases (125/300). Putative anti-inflammatory/immunomodulatory properties were cited in 64% of cases (213/332). Educational resources (41/92, 45%), team-based collaboration (29/92, 32%) and specialist consultation (10/92, 11%) were cited as the supportive basis for these prescription choices.Clinical significance: Veterinarians are using metronidazole frequently for non-antimicrobial properties in contradiction to antimicrobial use guidelines. Future stewardship programs should adapt guidance specifically to counter this prescribing behaviour.","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Small Animal Practice","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/jsap.13910","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: It is currently unknown how often antibiotics (including metronidazole) are used for non-antibacterial purposes in dogs and cats. This study looked to characterise the rationale for metronidazole prescription in these species.

Methods: Retrospective cohort study. Veterinarians reported clinical information for dogs and cats treated with metronidazole in the previous year, including the rationale for metronidazole selection.

Results: Three hundred and thirty-two cases were reported by 138 veterinarians describing metronidazole use in 47 cats and 285 dogs. Metronidazole was most commonly prescribed to treat acute diarrhoea (n = 156, 47%), chronic diarrhoea (n = 79, 24%) or giardiasis (n = 36, 11%). Veterinarians selected metronidazole exclusively for non-antimicrobial targeted therapy in 42% of cases (125/300). Putative anti-inflammatory/immunomodulatory properties were cited in 64% of cases (213/332). Educational resources (41/92, 45%), team-based collaboration (29/92, 32%) and specialist consultation (10/92, 11%) were cited as the supportive basis for these prescription choices.

Clinical significance: Veterinarians are using metronidazole frequently for non-antimicrobial properties in contradiction to antimicrobial use guidelines. Future stewardship programs should adapt guidance specifically to counter this prescribing behaviour.

查看原文本刊更多论文

了解在猫狗身上使用甲硝唑的基本原理。

目的：目前尚不清楚抗生素（包括甲硝唑）用于狗和猫非抗菌目的的频率。本研究旨在描述甲硝唑处方在这些物种中的基本原理。方法：回顾性队列研究。兽医报告了上一年用甲硝唑治疗的狗和猫的临床资料，包括选择甲硝唑的理由。结果：138名兽医报告了332例使用甲硝唑的病例，描述了47只猫和285只狗的使用情况。甲硝唑最常用于治疗急性腹泻（n = 156, 47%）、慢性腹泻（n = 79, 24%）或贾第虫病（n = 36, 11%）。42%（125/300）的兽医选择甲硝唑作为非抗菌药物靶向治疗。64%的病例（213/332）引用了假定的抗炎/免疫调节特性。教育资源（41/ 92,45 %）、团队协作（29/ 92,32 %）和专家咨询（10/ 92,11 %）是这些处方选择的支持基础。临床意义：兽医经常使用甲硝唑的非抗菌特性，这与抗菌使用指南相矛盾。未来的管理项目应该专门针对这种开处方的行为调整指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Small Animal Practice 农林科学-兽医学

CiteScore

3.30

自引率

6.20%

发文量

117

审稿时长

12-24 weeks

期刊介绍： Journal of Small Animal Practice (JSAP) is a monthly peer-reviewed publication integrating clinical research papers and case reports from international sources, covering all aspects of medicine and surgery relating to dogs, cats and other small animals. These papers facilitate the dissemination and implementation of new ideas and techniques relating to clinical veterinary practice, with the ultimate aim of promoting best practice. JSAP publishes high quality original articles, as well as other scientific and educational information. New developments are placed in perspective, encompassing new concepts and peer commentary. The target audience is veterinarians primarily engaged in the practise of small animal medicine and surgery. In addition to original articles, JSAP will publish invited editorials (relating to a manuscript in the same issue or a topic of current interest), review articles, which provide in-depth discussion of important clinical issues, and other scientific and educational information from around the world. The final decision on publication of a manuscript rests with the Editorial Board and ultimately with the Editor. All papers, regardless of type, represent the opinion of the authors and not necessarily that of the Editor, the Association or the Publisher. The Journal of Small Animal Practice is published on behalf of the British Small Animal Veterinary Association and is also the official scientific journal of the World Small Animal Veterinary Association