Sperm abnormality: Differential expression of microRNAs.

IF 3.2 3区医学 Q2 GENETICS & HEREDITY

Journal of Assisted Reproduction and Genetics Pub Date : 2025-06-30 DOI:10.1007/s10815-025-03562-x

Sara Rahbar, Behnaz Sadeghzadeh Oskouei, Nahid Azad, Jafar Rezaie, Rana Jahanban Esfahlan

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引用次数: 0

Abstract

Adult male fertility requires continuous production of sperm through the spermatogenesis process involving the correct timing of regulatory signals to spermatogonial stem cells (SSCs) to support continuous gamete generation. MicroRNAs (miRNAs) modulate gene expression post-transcriptionally and are shown to regulate various biological pathways in both humans and animal models. miRNAs in Sertoli cells and germ cells respond to regulatory signals and downregulate or upregulate required mRNAs and proteins that function in different pathways to support successful spermatogenesis. In addition, differential expression of miRNAs in sperm and seminal plasma of men with sperm disorders and normozoospermia is reported. However, the role of miRNAs in the pathogenesis of patients with sperm disorders and its mechanisms have not been comprehensively studied. The aim of this review is to describe the mechanisms through which the dysregulation of miRNAs can lead to male infertility. Further, the possibility of using miRNAs as diagnostic and therapeutic targets is discussed.

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精子异常：microRNAs的差异表达。

成年男性的生育能力需要通过精子发生过程持续产生精子，这一过程涉及到向精原干细胞（ssc）发出正确的调节信号，以支持配子的持续产生。MicroRNAs （miRNAs）通过转录后调节基因表达，并在人类和动物模型中调节各种生物途径。支持细胞和生殖细胞中的mirna响应调节信号，下调或上调在不同途径中支持成功精子发生所需的mrna和蛋白质。此外，有报道称，患有精子障碍和正常精子症的男性的精子和精浆中存在miRNAs的差异表达。然而，miRNAs在精子障碍患者发病机制中的作用及其机制尚未得到全面研究。这篇综述的目的是描述mirna失调导致男性不育的机制。此外，还讨论了使用mirna作为诊断和治疗靶点的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Assisted Reproduction and Genetics 医学-妇产科学

CiteScore

5.70

自引率

9.70%

发文量

286

审稿时长

1 months

期刊介绍： The Journal of Assisted Reproduction and Genetics publishes cellular, molecular, genetic, and epigenetic discoveries advancing our understanding of the biology and underlying mechanisms from gametogenesis to offspring health. Special emphasis is placed on the practice and evolution of assisted reproduction technologies (ARTs) with reference to the diagnosis and management of diseases affecting fertility. Our goal is to educate our readership in the translation of basic and clinical discoveries made from human or relevant animal models to the safe and efficacious practice of human ARTs. The scientific rigor and ethical standards embraced by the JARG editorial team ensures a broad international base of expertise guiding the marriage of contemporary clinical research paradigms with basic science discovery. JARG publishes original papers, minireviews, case reports, and opinion pieces often combined into special topic issues that will educate clinicians and scientists with interests in the mechanisms of human development that bear on the treatment of infertility and emerging innovations in human ARTs. The guiding principles of male and female reproductive health impacting pre- and post-conceptional viability and developmental potential are emphasized within the purview of human reproductive health in current and future generations of our species. The journal is published in cooperation with the American Society for Reproductive Medicine, an organization of more than 8,000 physicians, researchers, nurses, technicians and other professionals dedicated to advancing knowledge and expertise in reproductive biology.