Mesoporous Silica-Encapsulated Cerium Oxide Nanozymes and Quercetin for Synergistic ROS-Modulated Downregulation of Inflammatory Cytokines.

IF 6.6 2区医学 Q1 NANOSCIENCE & NANOTECHNOLOGY

International Journal of Nanomedicine Pub Date : 2025-06-25 eCollection Date: 2025-01-01 DOI:10.2147/IJN.S525411

Shanlei Zhou, Yu Zhang, Eudald Casals, Muling Zeng, Manuel Morales-Ruiz, Qingshi Liu, Bo Zhang, Gregori Casals

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引用次数: 0

Abstract

Introduction: Combining natural antioxidants with nanozymes represents a promising strategy to enhance therapeutic outcomes in oxidative stress-related diseases. This study integrates quercetin (Que), a plant-derived flavonoid with strong antioxidant activity, and cerium oxide nanozymes (CeO₂NZs) into mesoporous silica (mSiO₂) to enhance therapeutic efficacy and overcome the poor solubility and bioavailability of natural antioxidants.

Methods: Large-pore mSiO₂ (11 nm) were synthesized via a sol-gel method to encapsulate cerium oxide nanozymes (CeO₂NZs). Que was loaded using solvent impregnation to obtain (CeO₂/Que)@mSiO₂ nanocomposites. Structural and chemical characterization was performed, and biological evaluations were conducted in A549 cells.

Results: The incorporation of a large mesopore mSiO₂ (11 nm) significantly enhanced Que loading capacity and its sustained release in cell culture media. The (CeO₂/Que)@mSiO₂ nanocomposite demonstrated excellent biocompatibility, effective ROS scavenging, and significant downregulation of inflammatory cytokines (IL-1β, IL-6, TNF-α) compared to free Que.

Conclusion: The (CeO₂/Que)@mSiO₂ nanoplatform offers synergistic antioxidant and anti-inflammatory effects, supporting its potential for treating oxidative stress-related inflammatory conditions.

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介孔二氧化硅包封氧化铈纳米酶和槲皮素协同ros下调炎症细胞因子。

将天然抗氧化剂与纳米酶相结合是提高氧化应激相关疾病治疗效果的一种有前途的策略。本研究将槲皮素（Que），一种具有强抗氧化活性的植物来源类黄酮，和氧化铈纳米酶（CeO2NZs）整合到介孔二氧化硅（mSiO2）中，以提高治疗效果，克服天然抗氧化剂的溶解度和生物利用度差的问题。方法：采用溶胶-凝胶法制备大孔msio2 (11 nm)，包封氧化铈纳米酶（ceo2 NZs）。采用溶剂浸渍法制备（ceo2 /Que）@mSiO₂纳米复合材料。在A549细胞中进行结构和化学表征，并进行生物学评价。结果：大介孔mSiO 2 （11 nm）的掺入显著提高了Que在细胞培养基中的负载能力和缓释能力。与游离Que相比，（CeO₂/Que）@mSiO₂纳米复合材料具有优异的生物相容性，有效清除ROS，并显著下调炎症细胞因子（IL-1β, IL-6, TNF-α）。结论：（CeO₂/Que）@mSiO₂纳米平台具有协同抗氧化和抗炎作用，支持其治疗氧化应激相关炎症的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nanomedicine NANOSCIENCE & NANOTECHNOLOGY-PHARMACOLOGY & PHARMACY

CiteScore

14.40

自引率

3.80%

发文量

511

审稿时长

1.4 months

期刊介绍： The International Journal of Nanomedicine is a globally recognized journal that focuses on the applications of nanotechnology in the biomedical field. It is a peer-reviewed and open-access publication that covers diverse aspects of this rapidly evolving research area. With its strong emphasis on the clinical potential of nanoparticles in disease diagnostics, prevention, and treatment, the journal aims to showcase cutting-edge research and development in the field. Starting from now, the International Journal of Nanomedicine will not accept meta-analyses for publication.