The Distribution of HLA-DRB4 Alleles Among HLA-DRB1*07:01-Positive Haplotypes in Saudi Arabia.

IF 2.3 4区医学 Q3 GENETICS & HEREDITY

International Journal of Immunogenetics Pub Date : 2025-06-29 DOI:10.1111/iji.12715

Sheerin A Alandejani, Fatma Aytül Uyar, Abdullah Alrasheed, Mohammed Alghamdi, Asma Albaihed, Abdullah S Matyuri, Abdulrahman Alkhaibari, Aishah Alanazi, Mohammed Alzahrani, Abdullah Alshubaili, Hanan Anazi, Ali H Hajeer

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引用次数: 0

Abstract

This study investigates the distribution of human leukocyte antigen (HLA)-DRB4 alleles in HLA-DRB1*07:01-positive haplotypes within a Saudi cohort of 313 individuals. It identifies strong linkage disequilibrium between HLA-DRB1*07:01 and specific alleles. The most prevalent HLA-DRB1∼DQB1 combination identified is DRB1*07:01∼DQB1*02:02. Additionally, for the HLA-DRB1*07:01∼DQB1*03:03 association, DRB4*01:01 was found to be more common than the DRB4*01:03N allele. The most frequently observed extended haplotype is HLA-A*02:01∼C*06:02∼B*50:01∼DRB1*07:01∼DRB4*01:03∼DQA1*02:01∼DQB1*02:02∼DPA1*01:03∼DPB1*04:01. These findings emphasize the distinct genetic characteristics of the Saudi population and contribute to understanding haplotypic diversity, particularly the prevalence of HLA-DR7-related alleles and their implications for disease susceptibility and transplantation compatibility.

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沙特阿拉伯地区HLA-DRB1*07:01阳性单倍型HLA-DRB4等位基因的分布

本研究调查了313名沙特人HLA- drb1 *07:01阳性单倍型中人类白细胞抗原(HLA)-DRB4等位基因的分布。发现HLA-DRB1*07:01与特定等位基因之间存在强烈的连锁不平衡。最常见的HLA-DRB1 ~ DQB1组合是DRB1*07:01 ~ DQB1*02:02。此外，对于HLA-DRB1*07:01 ~ DQB1*03:03关联，发现DRB4*01:01比DRB4*01:03N等位基因更常见。最常见的扩展单倍型是HLA-A*02:01 ~ C*06:02 ~ B*50:01 ~ DRB1*07:01 ~ DRB4*01:03 ~ DQA1*02:01 ~ DQB1*02:02 ~ DPA1*01:03 ~ DPB1*04:01。这些发现强调了沙特人群独特的遗传特征，有助于理解单倍型多样性，特别是hla - dr7相关等位基因的患病率及其对疾病易感性和移植相容性的影响。

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来源期刊

International Journal of Immunogenetics 医学-免疫学

CiteScore

4.70

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.