Treatment and Survival Outcomes in Rhino-Orbital Mucormycosis with and without Orbital Exenteration: A Retrospective Case Series and Literature Review.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
International Medical Case Reports Journal Pub Date : 2025-06-24 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S530233
Shadi Boqaaiya, Yuval Cohen, Karine Beiruti Wiegler, Otzem Chassid
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引用次数: 0

Abstract

Rhino-orbital mucormycosis (ROM) is a life-threatening, fungal infection, primarily affecting immunocompromised patients. The role of orbital exenteration in treatment remains debated, especially regarding its impact on survival outcomes. This case series presents two patients from our Ophthalmology department and compares them with eight cases from the literature, focusing on treatment outcomes and survival rates. We specifically explore the impact of orbital exenteration and other management strategies. The analysis reveals that survival outcomes are closely linked to the timely initiation of antifungal therapy, the patient's underlying conditions, and the extent of orbital involvement at the time of diagnosis. Our findings, in line with the literature, show that early-stage ROM can be treated successfully with less invasive methods, while advanced cases may require orbital exenteration. The need for exenteration should be evaluated on a case-by-case basis, with early detection and appropriate antifungal treatment being critical factors for survival. This study highlights the importance of early diagnosis and individualized treatment plans, emphasizing that while orbital exenteration may improve survival in severe cases, less invasive interventions should be considered for less advanced ROM. Further research and standardized guidelines are needed to refine treatment strategies.

鼻-眶毛霉菌病伴或不伴鼻-眶毛霉菌病的治疗和生存结果:回顾性病例系列和文献综述。
鼻眶毛霉菌病(ROM)是一种危及生命的真菌感染,主要影响免疫功能低下的患者。眼眶剜除术在治疗中的作用仍有争议,特别是其对生存结果的影响。本病例系列介绍了我们眼科的两例患者,并将其与文献中的八例进行了比较,重点讨论了治疗结果和生存率。我们特别探讨了眼眶摘除和其他管理策略的影响。分析显示,生存结果与抗真菌治疗的及时开始、患者的基础条件和诊断时眼眶受损伤的程度密切相关。我们的研究结果与文献一致,表明早期ROM可以用微创方法成功治疗,而晚期病例可能需要眼眶清除。应根据具体情况评估清除的必要性,早期发现和适当的抗真菌治疗是生存的关键因素。本研究强调了早期诊断和个性化治疗计划的重要性,强调虽然眶内清除术可以提高严重病例的生存率,但对于不太严重的ROM应考虑微创干预。需要进一步的研究和标准化指南来完善治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Medical Case Reports Journal
International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
135
审稿时长
16 weeks
期刊介绍: International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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