Gustave Roussy Immune Score (GRImScore) as a Novel Prognostic Index for Stage III Gastric Cancer Patients: A Real-World Retrospective Study.

IF 2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2025-06-24 eCollection Date: 2025-01-01 DOI:10.2147/IJGM.S515795

Xiaofeng Zhao, Fen Zhang, Panpan Xing, Chunyan Jiang, Danqing Li, Dianchao Wu

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引用次数: 0

Abstract

Objective: This study aimed to investigate whether Gustave Roussy immune score (GRImScore) serves as a novel prognostic index for predicting survival in patients with advanced gastric cancer.

Methods: GRImScore was based on three objective markers: (1) albumin level (<3.5 g/L = 1 point, ≥3.5 g/L = 0 point); (2) lactate dehydrogenase level (≥250 U/L = 1 point, <250 U/L = 0 point); (3) neutrophil to lymphocyte ratio (NLR) (≥2.70 = 1 point, <2.70 = 0 point). According to GRImScore, these patients were divided into low GRImScore group (0 points) and high GRImScore group (1, 2, or 3 points). Kaplan-Meier method was applied to draw survival curves for disease free survival (DFS) and overall survival (OS), and differences among these groups were analyzed using Log rank tests. Univariate and multivariate Cox proportional hazards models were used to analyze the relationship between the enrolled parameters and OS. Nomograms were developed based on the results of multivariate Cox regression analysis using the consistency index (C-index) and decision curve analyses (DCA) for internal validation.

Results: Based on GRImScore, 134 patients were in low GRImScore group and 61 were in high GRImScore group. The median DFS and OS in low GRImScore group were significantly longer than that in high GRImScore group (DFS: 40.52 months vs 22.83 months, χ²=7.033, P=0.0080; OS: 55.07 months vs 31.83 months, χ²=6.328, P=0.0119). According to multivariable Cox analysis, GRImScore was significantly associated with DFS (HR, 2.798; 95% CI: 1.711-11.008, P = 0.001) and OS (HR, 2.631; 95% CI: 1.645-10.725, P = 0.001). The nomogram constructed by multivariate Cox analysis showed good performance in predicting DFS (C-index: 0.717, 95% CI: 0.595-0.814) and OS (C-index: 0.725, 95% CI: 0.605-0.819).

Conclusion: GRImScore, a novel prognostic index, is a prognostic indicator for patients with advanced gastric cancer. Nomograms based on the GRImScore showed good predictive ability.

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Gustave Roussy免疫评分（GRImScore）作为III期胃癌患者新的预后指标：一项真实世界回顾性研究

目的：本研究旨在探讨Gustave Roussy免疫评分（GRImScore）能否作为预测晚期胃癌患者生存的一种新的预后指标。方法：根据三个客观指标进行评分：(1)白蛋白水平(结果：根据GRImScore评分，低评分组134例，高评分组61例。低评分组的中位DFS和OS明显长于高评分组(DFS: 40.52个月vs 22.83个月，χ2=7.033， P=0.0080；OS: 55.07个月vs 31.83个月，χ2=6.328， P=0.0119)。多变量Cox分析显示，GRImScore与DFS显著相关(HR, 2.798；95% CI: 1.711-11.008, P = 0.001)和OS (HR, 2.631；95% ci: 1.645-10.725, p = 0.001)。多变量Cox分析构建的nomogram对DFS （C-index: 0.717, 95% CI: 0.595 ~ 0.814）和OS （C-index: 0.725, 95% CI: 0.605 ~ 0.819）具有较好的预测效果。结论：GRImScore是一种新的预后指标，可作为晚期胃癌患者的预后指标。基于GRImScore的nomogram预测能力较好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.