Histamine H3 receptor: an emerging target for cancer therapy?

Abstract

Achieving better clinical outcomes in cancer research requires a deeper understanding of tumoral biology and the application of this knowledge within a clinic setting. The aim of this review is to briefly summarize the current knowledge on H₃R molecular pharmacology, the clinical use of H₃R antagonists, and the most recent findings reporting H₃R role in cancer biology. We will discuss in detail the current landscape and clinical perspectives of the modulation of this H₃R on cancer progression and treatment. We propose H₃R as a promising molecular target for cancer drug repurposing and development.