The role of gangliosides in male reproduction.

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Kai Wang, Ying Feng, Fang Ma, Jiajie Li, Jing Chen, Xue Ma
{"title":"The role of gangliosides in male reproduction.","authors":"Kai Wang, Ying Feng, Fang Ma, Jiajie Li, Jing Chen, Xue Ma","doi":"10.1093/glycob/cwaf036","DOIUrl":null,"url":null,"abstract":"<p><p>Male reproduction is a complex process governed by sophisticated cellular and molecular pathways including sperm production, maturation, and delivery. This review underscores the indispensable role of gangliosides-sialic acid-bearing glycosphingolipids prevalent in the male reproductive system-as key modulators of sperm functionality. Gangliosides, which consist of a ceramide core linked to oligosaccharide chains, are predominantly found on cell plasma membranes, where they play crucial roles in cell signaling, adhesion, recognition, and membrane structure. Extensive research has revealed gangliosides' dynamic contributions to various facets of sperm physiology, such as maturation, capacitation, the acrosome reaction, and ultimately, fertilization. Variability in ganglioside composition and localization during different sperm development stages and within specific areas of the male reproductive tract underscores their importance in sperm functionality and reproductive outcome. Furthermore, disruptions in ganglioside synthesis, transport and distribution on the membrane or surrounding molecules have been associated with male infertility and reproductive dysfunctions, positioning them as potential biomarkers for these conditions. The findings presented in this review not only advance our understanding of the biochemical landscape of male fertility but also propose gangliosides as potential targets for therapeutic intervention, offering a promising avenue for addressing male reproductive disorders. The exploration of gangliosides in the context of male reproduction not only enhances our understanding of male fertility but also paves the way for novel diagnostic and therapeutic strategies in reproductive health. These insights emphasize the urgency and significance of further investigative efforts into ganglioside functions to potentially revolutionize the diagnosis and treatment of male reproductive abnormalities.</p>","PeriodicalId":12766,"journal":{"name":"Glycobiology","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Glycobiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1093/glycob/cwaf036","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Male reproduction is a complex process governed by sophisticated cellular and molecular pathways including sperm production, maturation, and delivery. This review underscores the indispensable role of gangliosides-sialic acid-bearing glycosphingolipids prevalent in the male reproductive system-as key modulators of sperm functionality. Gangliosides, which consist of a ceramide core linked to oligosaccharide chains, are predominantly found on cell plasma membranes, where they play crucial roles in cell signaling, adhesion, recognition, and membrane structure. Extensive research has revealed gangliosides' dynamic contributions to various facets of sperm physiology, such as maturation, capacitation, the acrosome reaction, and ultimately, fertilization. Variability in ganglioside composition and localization during different sperm development stages and within specific areas of the male reproductive tract underscores their importance in sperm functionality and reproductive outcome. Furthermore, disruptions in ganglioside synthesis, transport and distribution on the membrane or surrounding molecules have been associated with male infertility and reproductive dysfunctions, positioning them as potential biomarkers for these conditions. The findings presented in this review not only advance our understanding of the biochemical landscape of male fertility but also propose gangliosides as potential targets for therapeutic intervention, offering a promising avenue for addressing male reproductive disorders. The exploration of gangliosides in the context of male reproduction not only enhances our understanding of male fertility but also paves the way for novel diagnostic and therapeutic strategies in reproductive health. These insights emphasize the urgency and significance of further investigative efforts into ganglioside functions to potentially revolutionize the diagnosis and treatment of male reproductive abnormalities.

神经节苷在男性生殖中的作用。
男性生殖是一个复杂的过程,由复杂的细胞和分子途径控制,包括精子的产生、成熟和分娩。这篇综述强调了在男性生殖系统中普遍存在的神经节苷类-含唾液酸的鞘糖脂-作为精子功能的关键调节剂的不可或缺的作用。神经节苷类化合物主要存在于细胞膜上,在细胞信号传导、粘附、识别和膜结构等方面起着至关重要的作用。广泛的研究揭示了神经节苷类对精子生理的各个方面的动态贡献,如成熟、获能、顶体反应以及最终的受精。在不同精子发育阶段和男性生殖道特定区域,神经节苷脂组成和定位的变异性强调了它们在精子功能和生殖结果中的重要性。此外,神经节苷脂在膜或周围分子上的合成、运输和分布的破坏与男性不育和生殖功能障碍有关,将其定位为这些疾病的潜在生物标志物。本综述的研究结果不仅促进了我们对男性生育的生化景观的理解,而且还提出了神经节苷脂作为治疗干预的潜在靶点,为解决男性生殖障碍提供了一条有希望的途径。在男性生殖的背景下对神经节苷类的探索不仅增强了我们对男性生育能力的理解,而且为生殖健康的新诊断和治疗策略铺平了道路。这些见解强调了进一步研究神经节苷脂功能的紧迫性和重要性,以潜在地彻底改变男性生殖异常的诊断和治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Glycobiology
Glycobiology 生物-生化与分子生物学
CiteScore
7.50
自引率
4.70%
发文量
73
审稿时长
3 months
期刊介绍: Established as the leading journal in the field, Glycobiology provides a unique forum dedicated to research into the biological functions of glycans, including glycoproteins, glycolipids, proteoglycans and free oligosaccharides, and on proteins that specifically interact with glycans (including lectins, glycosyltransferases, and glycosidases). Glycobiology is essential reading for researchers in biomedicine, basic science, and the biotechnology industries. By providing a single forum, the journal aims to improve communication between glycobiologists working in different disciplines and to increase the overall visibility of the field.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信