Shihang Li, Guobao Pang, Rong Li, Qinying Shi, Yannan Xu, Ying Lu, Jianbo Song
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引用次数: 0
Abstract
Purpose: To compare the 3D-printed oral stents (3D-OS) and personalised hand-made stents in dentistry (DentStent) for head and neck malignancies.
Methods: Twelve patients with head and neck malignant tumours in the Cancer Centre of Shanxi Bethune Hospital from 1 August 2023 to 31 September 2024 were admitted to the study. After obtaining informed consent from the patients, 3D-OS and DentStent were designed for each patient, respectively, and the patients wore them to produce two groups of radiotherapy plans. The aim was to compare the homogeneity index (HI) and conformity index (CI) of the target areas, as well as the dose differences to the organs at risk (OAR) between the two plans. Additionally, the satisfaction of the patients with the stents after use was assessed.
Results: The difference in HI, CI and OAR dose to the target area between the two groups was slight, but 3D-OS took less time (∼4 h) to fabricate and resulted in higher resolution and patient satisfaction.
Conclusion: The proposed 3D-OS could obtain good HI and CI in radiotherapy for head and neck malignancies, and is a new method for rapid and satisfactory personalised oral stent.
期刊介绍：
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.
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