Optimising Early Intervention: A Retrospective Study on the Role of Hyperbaric Oxygen Therapy in Enhancing Hearing Recovery for Sudden Sensorineural Hearing Loss.

IF 1.5 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2025-06-29 DOI:10.1111/coa.70004

Bang-Yan Zhang, Tzong-Yun Tsai, Kai-Chieh Chan

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引用次数: 0

Abstract

Purpose: This study aimed to evaluate the efficacy of hyperbaric oxygen therapy (HBOT) as an adjunct to corticosteroids in the treatment of sudden sensorineural hearing loss (SSNHL) and to determine the optimal timing for HBOT initiation, considering the severity of initial hearing loss.

Methods: A retrospective review was conducted on 128 patients diagnosed with unilateral SSNHL who received corticosteroids and HBOT. The inclusion criteria were the initiation of steroid treatment within 14 days and HBOT within 30 days of SSNHL onset, with at least five HBOT sessions completed. Audiometric evaluations were performed pre- and post-treatment to assess hearing gains. Statistical analyses, including logistic regression and ROC curves, were utilised to identify factors influencing hearing recovery.

Results: The results showed that 72.7% of patients experienced significant hearing improvement. Early initiation of HBOT within 12.5 days of onset was associated with better hearing outcomes. Multivariate analysis and sensitivity testing further confirmed that HBOT timing was the most robust predictor of hearing gain, independent of baseline hearing severity.

Conclusion: Early HBOT initiation, particularly within 12.5 days, enhances hearing recovery in SSNHL patients. These findings support the use of HBOT as a valuable adjunctive treatment and underscore the need for standardised protocols in future studies.

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优化早期干预：高压氧治疗在突发性感音神经性听力损失中促进听力恢复作用的回顾性研究。

目的：本研究旨在评估高压氧治疗（HBOT）作为糖皮质激素辅助治疗突发性感音神经性听力损失（SSNHL）的疗效，并考虑初始听力损失的严重程度，确定HBOT启动的最佳时机。方法：回顾性分析128例单侧SSNHL患者接受糖皮质激素和HBOT治疗。纳入标准为SSNHL发病后14天内开始类固醇治疗，30天内开始HBOT治疗，至少完成5次HBOT治疗。治疗前后分别进行听力测量评估，以评估听力增益。采用logistic回归和ROC曲线进行统计分析，确定影响听力恢复的因素。结果：72.7%的患者听力有明显改善。在发病12.5天内早期开始HBOT与更好的听力结果相关。多变量分析和敏感性测试进一步证实，HBOT时间是听力增加最可靠的预测因子，与基线听力严重程度无关。结论：早期启动HBOT，特别是在12.5天内，可促进SSNHL患者的听力恢复。这些发现支持使用HBOT作为一种有价值的辅助治疗，并强调在未来的研究中需要标准化的方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.