6-Deoxy-6-[ 18 F]Fluoro-L-Ascorbic Acid PET/CT in the Detection of Lymph Node Metastases for Postoperative Differentiated Thyroid Cancer Patients : Using Histopathology as Reference Standard.
IF 9.6 3区 医学Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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引用次数: 0
Abstract
Background: 6-Deoxy-6-[ 18 F]fluoro-L-ascorbic acid ([ 18 F]FAA) is a radioisotope-labeled analogue of ascorbic acid (AA), designed to investigate oxidative stress and AA accumulation in vivo by PET imaging. It has also been reported as a promising radiotracer for tumor detection, particularly in metastatic differentiated thyroid cancer (DTC).
Purpose: This study aimed to evaluate the diagnostic potential of [ 18 F]FAA in detecting lymph node metastases in postoperative DTC patients.
Methods: Patients who have undergone thyroidectomy for DTC and are either preparing for 131 I therapy or undergoing follow-up examinations were prospectively enrolled and underwent [ 18 F]FAA PET/CT from September 2023 to November 2023. Histopathologic results served as gold standard for final diagnosis.
Results: A total of 70 patients [mean age, 40.5 y±12.0 (SD); 23 men] with pathologically confirmed DTC were enrolled. At patient-based analysis, [ 18 F]FAA PET/CT detected positive lymph nodes in all patients, with an accuracy of 92.9% (65/70). At lesion-based analysis of patients who underwent central and/or lateral cervical lymph node dissection, the accuracy of [ 18 F]FAA PET/CT were 94.3% (460/488). The SUVmax and TBR of lymph node metastases were significantly higher than normal lymph nodes (mean SUVmax, 8.3±4.6 vs. 2.0±1.5, P <0.0001; mean TBR, 3.6±2.2 vs. 0.9±0.7, P <0.0001).
Conclusions: [ 18 F]FAA PET/CT can be used in the detection of postoperative cervical lymph node metastases in DTC. It may serve as a valuable tool for risk stratification and radioactive iodine treatment decision-making of postoperative DTC.
期刊介绍:
Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty.
Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.