Optimized synthesis of aroyl-S,N-ketene acetals by omission of solubilizing alcohol cosolvents.

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2025-06-20 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.97

Julius Krenzer, Thomas J J Müller

引用次数: 0

Abstract

Aroyl-S,N-ketene acetals are obtained by condensation of aroyl chlorides and 2-methyl-N-benzylbenzothiazolium salts in 1,4-dioxane at room temperature in short reaction time in 20-99% yield. This protocol represents a considerable improvement over the standard synthesis in 1,4-dioxane/ethanol mixtures at elevated temperatures.

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省略醇共溶剂，优化了芳烃- s， n -烯酮缩醛的合成。

在室温下，芳烃氯与2-甲基- n -苄基苯并噻唑盐在1,4-二恶烷中缩合，反应时间短，产率为20-99%，得到了芳烃- s， n -烯酮缩醛。该方案代表了在1,4-二恶烷/乙醇混合物中在高温下的标准合成的相当大的改进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

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