Resolving anxiety-like behaviour inconsistencies in the elevated plus maze by tracking exploration depth and timing.

IF 4.6 2区 心理学 Q1 PSYCHOLOGY, EXPERIMENTAL
Matthew D Zelko, Stephen R Robinson, Elisa L Hill-Yardin, Helen Nasser
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引用次数: 0

Abstract

The anxiety-like behaviour provoked by the elevated plus maze is primarily measured by the degree to which a rodent explores or avoids the risker, unenclosed arms. Measures such as arm entries and total time spent within the arm are conventionally used, but their analysis often produces inconsistent inferences about the level of anxiety-like behaviour being observed. This inconsistency occurs because the measures do not correlate with one another, raising the question of how validly they capture both the exploratory and avoidance motivations that typify anxiety-like behaviour. Given this inconsistency, we propose a new measure, Novel Exploration Growth, that captures avoidance and exploratory behaviours within the maze. The growth of novel exploration tracks the first visit to discrete areas of the maze over time. The absolute amount of novel exploration, combined with the phasic nature of the exploration, reveals behavioural phenotypes with both avoidance and exploration quantified in a single time series. By addressing both motivations evoked by the maze through a single coherent measure, we provide a superior estimation of anxiety-like behaviour and resolve inconsistencies that arise when applying conventional measures alone.

通过跟踪探索深度和时间,解决高架+迷宫中类似焦虑的行为不一致。
由高架+迷宫引起的类似焦虑的行为主要是通过啮齿动物探索或避免风险的程度来衡量的,没有封闭的手臂。通常使用诸如手臂进入和在手臂内花费的总时间等测量方法,但他们的分析通常会对观察到的焦虑样行为的水平产生不一致的推断。之所以出现这种不一致,是因为这些测量方法彼此之间并不相关,这就提出了一个问题,即它们如何有效地捕捉到典型的焦虑类行为的探索动机和回避动机。鉴于这种不一致,我们提出了一种新的测量方法,新颖的探索增长,捕捉迷宫中的回避和探索行为。随着时间的推移,新探索的增长追踪了迷宫中离散区域的第一次访问。新探索的绝对数量,结合探索的阶段性,揭示了在单个时间序列中量化的回避和探索的行为表型。通过单一连贯的测量来解决迷宫引起的两种动机,我们提供了对焦虑样行为的优越估计,并解决了单独应用常规测量时出现的不一致。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.30
自引率
9.30%
发文量
266
期刊介绍: Behavior Research Methods publishes articles concerned with the methods, techniques, and instrumentation of research in experimental psychology. The journal focuses particularly on the use of computer technology in psychological research. An annual special issue is devoted to this field.
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