{"title":"Role of non-coding RNAs in human-papillomavirus-associated cutaneous neoplasms.","authors":"Niloofar Faraji, Hassan Vahidnezhad, Narges Eslami, Tahereh Zeinali, Mohammad Shenagari, Dariush Shanehbandi, Arnavaz Hajizadeh Barfejani","doi":"10.1007/s00705-025-06335-0","DOIUrl":null,"url":null,"abstract":"<p><p>The increasing prevalence of skin cancers, including squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma, is driven by a multifaceted interaction of genetic, epigenetic, and environmental influences, with human papillomavirus (HPV) infection playing a notable role in some cases. This review explores the connection between HPV and host non-coding RNAs (ncRNAs), focusing on their involvement in skin cancer development, and emphasizes the pivotal role of ncRNAs in regulating both viral replication and oncogenic processes within host cells. We discuss the ways in which HPV exploits host cell ncRNAs, such as microRNAs (miRNAs) and long ncRNAs (lncRNAs), to facilitate carcinogenesis. Elucidating the mechanisms of HPV-ncRNA interactions will allow the critical role of ncRNAs in virus-host dynamics to be better understood, possibly allowing ncRNAs to be used as biomarkers for early cancer detection.</p>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 8","pages":"170"},"PeriodicalIF":2.5000,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Virology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00705-025-06335-0","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The increasing prevalence of skin cancers, including squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma, is driven by a multifaceted interaction of genetic, epigenetic, and environmental influences, with human papillomavirus (HPV) infection playing a notable role in some cases. This review explores the connection between HPV and host non-coding RNAs (ncRNAs), focusing on their involvement in skin cancer development, and emphasizes the pivotal role of ncRNAs in regulating both viral replication and oncogenic processes within host cells. We discuss the ways in which HPV exploits host cell ncRNAs, such as microRNAs (miRNAs) and long ncRNAs (lncRNAs), to facilitate carcinogenesis. Elucidating the mechanisms of HPV-ncRNA interactions will allow the critical role of ncRNAs in virus-host dynamics to be better understood, possibly allowing ncRNAs to be used as biomarkers for early cancer detection.
期刊介绍：
Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.
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