A Preliminary Meta-analysis of Regulatory T-cell Reduction in Patients With Migraine.

IF 1 Q4 NEUROSCIENCES

Basic and Clinical Neuroscience Pub Date : 2024-09-01 DOI:10.32598/bcn.15.5.2447.2

Subalakshmi Sugumar, Saman Shah, Philo Hazeena, Deepa Avadhani, Pavithra Murugan, Murugesan Arumugam

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引用次数: 0

Abstract

Introduction: The etiology of migraine is not fully understood, but there is ongoing debate about the potential role of immune dysfunction in migraine pathophysiology. Some clinical studies have shown a reduction in CD4⁺CD25⁺ regulatory T-cells (Treg) in migraine patients compared to healthy people. However, these studies have not been systematically analyzed. The primary objective of this study is to conduct a systematic review of Treg level changes in migraine patients.

Methods: A detailed literature search was conducted on PubMed, Scopus, Embase, ProQuest, Cochrane Review, Clinical trials, Academic thesis, American Academy of Neurology resources, and Google Scholar databases from 2010 to 2023. Studies that were appropriately designed to quantify Treg cell levels in migraine patients were included in this meta-analysis.

Results: Out of 17 studies initially reviewed, only 4 studies with 121 migraine patients were included for analysis. The meta-analysis revealed a statistically significant reduction in Treg cell levels in migraine patients compared to healthy volunteers (Z=1.21; P=0.23).

Conclusion: The observation of lower levels of Treg cells in migraine patients, compared to healthy volunteers, supports the theory that migraine may be an autoimmune disorder. However, additional clinical data is required to understand the role of immune dysregulation in migraine pathogenesis fully. This is the first meta-analysis of Treg cell levels in the context of migraine research, significantly contributing to the existing literature on the topic.

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偏头痛患者调节性t细胞减少的初步meta分析。

引言：偏头痛的病因尚不完全清楚，但关于免疫功能障碍在偏头痛病理生理中的潜在作用一直存在争议。一些临床研究表明，与健康人相比，偏头痛患者的CD4+CD25+调节性t细胞（Treg）减少。然而，这些研究并没有得到系统的分析。本研究的主要目的是对偏头痛患者的Treg水平变化进行系统回顾。方法：检索2010 - 2023年PubMed、Scopus、Embase、ProQuest、Cochrane Review、临床试验、学术论文、American Academy of Neurology资源、谷歌Scholar等数据库的详细文献。本荟萃分析纳入了适当设计的研究，以量化偏头痛患者的Treg细胞水平。结果：在最初审查的17项研究中，只有4项涉及121名偏头痛患者的研究被纳入分析。荟萃分析显示，与健康志愿者相比，偏头痛患者的Treg细胞水平有统计学意义上的显著降低(Z=1.21；P = 0.23)。结论：与健康志愿者相比，偏头痛患者的Treg细胞水平较低，这支持了偏头痛可能是一种自身免疫性疾病的理论。然而，需要更多的临床数据来充分了解免疫失调在偏头痛发病机制中的作用。这是偏头痛研究背景下首个Treg细胞水平的荟萃分析，对该主题的现有文献有重大贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Basic and Clinical Neuroscience NEUROSCIENCES-

CiteScore

2.60

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： BCN is an international multidisciplinary journal that publishes editorials, original full-length research articles, short communications, reviews, methodological papers, commentaries, perspectives and “news and reports” in the broad fields of developmental, molecular, cellular, system, computational, behavioral, cognitive, and clinical neuroscience. No area in the neural related sciences is excluded from consideration, although priority is given to studies that provide applied insights into the functioning of the nervous system. BCN aims to advance our understanding of organization and function of the nervous system in health and disease, thereby improving the diagnosis and treatment of neural-related disorders. Manuscripts submitted to BCN should describe novel results generated by experiments that were guided by clearly defined aims or hypotheses. BCN aims to provide serious ties in interdisciplinary communication, accessibility to a broad readership inside Iran and the region and also in all other international academic sites, effective peer review process, and independence from all possible non-scientific interests. BCN also tries to empower national, regional and international collaborative networks in the field of neuroscience in Iran, Middle East, Central Asia and North Africa and to be the voice of the Iranian and regional neuroscience community in the world of neuroscientists. In this way, the journal encourages submission of editorials, review papers, commentaries, methodological notes and perspectives that address this scope.