Mikaela M Weeder, Michael D Kleinhenz, Emily J Reppert, Andrew K Curtis, Abbie V Viscardi, Ally Leslie, Misty Bear, Bailey Fritz, Payton Dahmer, Johann F Coetzee
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引用次数: 0
Abstract
Objective: This study evaluated the analgesic effects of firocoxib, meloxicam, and transdermal flunixin in meat-type goats with experimentally induced lameness.
Methods: 44 crossbred castrated meat-type goats with an average weight of 35 kg (range, 25 to 43 kg) were enrolled from June to December 2022. Lameness was induced with amphotericin B injected in the distal interphalangeal joint of the left hind lateral claw. After a washout period, lameness was reproduced in the right hind limb. Eleven treatment groups were implemented: firocoxib (0.5, 1.0, and 2.0 mg/kg), meloxicam (1.0, 2.0, and 3.0 mg/kg, transdermal flunixin (3.3, 4.2, and 5.0 mg/kg), and positive and negative control. Outcome measurements included infrared thermography, mechanical nociception threshold, plasma cortisol, plasma substance P, kinetic gait analysis, visual lameness scoring, and visual analog scoring and were collected at -24, 0, 1, 2, 3, 4, 6, 8, 10, 12, 24, 36, 48, 60, and 72 hours relative to lameness induction.
Results: Transdermal flunixin at 3.3 and 5.0 mg/kg demonstrated the greatest analgesic effects from outcome measurements collected.
Conclusions: Transdermal flunixin meglumine provides the most effective analgesia for goats with induced lameness, suggesting it may be the preferred option for pain relief in goats with lameness symptoms.
Clinical relevance: Transdermal flunixin meglumine at 3.3 or 5.0 mg/kg provided the best results for pain mitigation in goats with induced lameness.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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