Epirubicin-sensitive detection with a CoWO₄/reduced graphene oxide modified screen-printed electrode.

IF 4.3 Q2 CHEMISTRY, MEDICINAL

ADMET and DMPK Pub Date : 2025-05-08 eCollection Date: 2025-01-01 DOI:10.5599/admet.2733

Somayeh Tajik, Razieh Moghimian, Hadi Beitollahi

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引用次数: 0

Abstract

Background and purpose: Because of its antimetabolic and cytotoxic qualities, epirubicin (EP), a crucial chemotherapeutic drug, has been used to treat a number of cancers, including those of the prostate, breast, ovary, stomach, lung, and colon.

Experimental approach: In this study, CoWO₄/reduced graphene oxide (CoWO₄/rGO) nanocomposite was synthesised and characterised by field emission-scanning electron microscopy and energy-dispersive X-ray spectroscopy. To provide a novel sensing platform for EP determination, a screen-printed electrode (SPE) surface was modified using the as-fabricated CoWO₄/rGO nanocomposite.

Key results: Using voltammetric techniques, the electrochemical behaviour of the CoWO₄/rGO nanocomposite modified SPE (CoWO₄/rGO/SPE) for the EP detection was examined. CoWO₄/rGO significantly reduced the overpotential of the EP redox reaction and increased the rate of electron transfer between the electrode and analyte as compared to bare SPE. EP was quantitatively analysed using differential pulse voltammetry.

Conclusions: It was discovered that the linearity range was 0.01 to 190.0 μM. The sensitivity and limit of detection were 0.1529 μA μM^-1 and 0.007 μM, respectively. Additionally, the constructed CoWO₄/rGO/SPE sensor's practical applicability was investigated in pharmaceutical samples with good recovery outcomes.

Abstract Image

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CoWO4/还原氧化石墨烯修饰丝网印刷电极的表柔比星敏感检测。

背景和目的：表柔比星（epi）是一种重要的化疗药物，由于其抗代谢和细胞毒性，已被用于治疗多种癌症，包括前列腺癌、乳腺癌、卵巢癌、胃癌、肺癌和结肠癌。实验方法：本研究合成了CoWO4/还原氧化石墨烯（CoWO4/rGO）纳米复合材料，并通过场发射扫描电镜和能量色散x射线能谱对其进行了表征。为了提供一种新型的电位检测平台，利用制备的CoWO4/rGO纳米复合材料修饰了丝网印刷电极（SPE）表面。利用伏安技术，考察了CoWO4/rGO纳米复合材料修饰的SPE （CoWO4/rGO/SPE）在EP检测中的电化学行为。与纯SPE相比，CoWO4/rGO显著降低了EP氧化还原反应的过电位，提高了电极和被分析物之间的电子传递速率。用差分脉冲伏安法定量分析EP。结论：在0.01 ~ 190.0 μM的线性范围内。检测灵敏度为0.1529 μA μM-1，检出限为0.007 μM。此外，还考察了构建的CoWO4/rGO/SPE传感器在药物样品中的实用性，并取得了良好的回收效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ADMET and DMPK Multiple-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ADMET and DMPK is an open access journal devoted to the rapid dissemination of new and original scientific results in all areas of absorption, distribution, metabolism, excretion, toxicology and pharmacokinetics of drugs. ADMET and DMPK publishes the following types of contributions: - Original research papers - Feature articles - Review articles - Short communications and Notes - Letters to Editors - Book reviews The scope of the Journal involves, but is not limited to, the following areas: - physico-chemical properties of drugs and methods of their determination - drug permeabilities - drug absorption - drug-drug, drug-protein, drug-membrane and drug-DNA interactions - chemical stability and degradations of drugs - instrumental methods in ADMET - drug metablic processes - routes of administration and excretion of drug - pharmacokinetic/pharmacodynamic study - quantitative structure activity/property relationship - ADME/PK modelling - Toxicology screening - Transporter identification and study