Anisotropic Magnetic Heating for Adaptive Thermal Ablation.

IF 27.4 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Sangmo Liu, Haopu Liang, Zonghu Han, Kevin J Anderton, Bat-Erdene Namsrai, Erik B Finger, John C Bischof, Yadong Yin
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Abstract

Thermal ablation provides minimally invasive treatment for cardiovascular and cerebrovascular conditions but risks damaging healthy tissues due to their low imaging contrast against diseased areas. This study introduces an adaptive thermal ablation probe leveraging anisotropic magnetic heating of magnetite nanorods pre-aligned within a polymer substrate. During magnetic pre-alignment, the nanorods form chain-like aggregates, enhancing their magnetic anisotropy and minimizing demagnetization effects. Under an alternating magnetic field, these features create a distinct difference in heat generation along the aggregates' easy and hard axes. This probe utilizes a bimorph structure incorporating a heating layer with aligned nanorods and an actuation layer containing NdFeB microparticles. Exposure to static and alternating magnetic fields induces probe bending, adjusting nanorod orientation to modulate heat generation and prevent overheating. In vitro experiments demonstrate successful thrombus phantom ablation in both fluid flow and porcine artery models while preserving tissue viability. This innovative approach advances thermal ablation technology by offering a safer, more precise, and adaptive solution with a high potential for clinical translation.

自适应热消融的各向异性磁加热。
热消融为心脑血管疾病提供了微创治疗,但由于其对病变区域的成像对比度较低,有损伤健康组织的风险。本研究介绍了一种自适应热烧蚀探针,利用在聚合物衬底内预先排列的磁铁矿纳米棒的各向异性磁加热。在磁预对准过程中,纳米棒形成链状聚集体,增强了它们的磁各向异性并最小化了退磁效应。在交变磁场的作用下,这些特征在聚集体的易轴和硬轴上产生的热量上产生了明显的差异。该探针采用双晶片结构,包括具有对齐纳米棒的加热层和含有钕铁硼微粒的驱动层。暴露在静态和交变磁场中会引起探针弯曲,调整纳米棒的方向以调节热量产生并防止过热。体外实验表明,在保持组织活力的同时,在流体流动和猪动脉模型中成功地进行了血栓幻影消融。这种创新的方法提供了一种更安全、更精确、适应性强的解决方案,具有很高的临床转化潜力,从而推动了热消融技术的发展。
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来源期刊
Advanced Materials
Advanced Materials 工程技术-材料科学:综合
CiteScore
43.00
自引率
4.10%
发文量
2182
审稿时长
2 months
期刊介绍: Advanced Materials, one of the world's most prestigious journals and the foundation of the Advanced portfolio, is the home of choice for best-in-class materials science for more than 30 years. Following this fast-growing and interdisciplinary field, we are considering and publishing the most important discoveries on any and all materials from materials scientists, chemists, physicists, engineers as well as health and life scientists and bringing you the latest results and trends in modern materials-related research every week.
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