Activatable and Renal Metabolizable NIR-II Emissive Au Nanoprobe for Real-Time Monitoring of Kidney GSH.

IF 9.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-07-16 Epub Date: 2025-06-30 DOI:10.1021/acs.nanolett.5c02358

Xingwang Wen, Yao Xu, Zhixin Chen, Jiayu Tian, Hao Zhong, Ruocheng Wu, Songjun Zeng

引用次数: 0

Abstract

Glutathione (GSH) plays a crucial role in maintaining redox homeostasis in the kidneys. Therefore, achieving real-time dynamic monitoring of renal GSH is of significant importance for the early diagnosis and prevention of kidney oxidative-reductive imbalance. Herein, intelligently activatable and renally clearable second near-infrared (NIR-II) emissive gold nanoclusters (Au NCs) were designed for real-time dynamic monitoring of renal GSH expression levels. The designed Au NCs were transported into the kidneys via the bloodstream and rapidly activated by intrarenal GSH, resulting in activated NIR-II fluorescence. More importantly, the in situ dynamic monitoring of the renal GSH change induced by the anethole trithione (ATT) and l-buthionine-sulfoximine (L-BSO) drugs was successfully achieved. Additionally, activated Au NCs can be quickly cleared and excreted through urine. These findings provide a new strategy for the in situ, real-time dynamic monitoring of renal GSH expression levels.

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可激活和肾代谢NIR-II发射金纳米探针实时监测肾脏谷胱甘肽。

谷胱甘肽（GSH）在维持肾脏氧化还原稳态中起着至关重要的作用。因此，实现肾脏谷胱甘肽的实时动态监测，对于早期诊断和预防肾脏氧化还原失衡具有重要意义。本文设计了智能激活和肾脏清除的第二近红外（NIR-II）发射金纳米团簇（Au NCs），用于实时动态监测肾脏GSH表达水平。设计的Au NCs通过血流进入肾脏，并被肾内GSH快速激活，导致NIR-II荧光激活。更重要的是，成功实现了甲醚三硫酮（ATT）和l-丁硫氨酸-亚砜胺（L-BSO）药物致肾GSH变化的原位动态监测。此外，活化的金细胞可以迅速清除并通过尿液排出体外。这些发现为原位实时动态监测肾GSH表达水平提供了新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.