Copper-Catalyzed Sulfonamidation of N,N-Dimethyl Formamide via C(sp3)─H Bond Functionalization

Abstract

We have developed a novel strategy for the direct sulfonamidation of N,N-dimethyl formamide through a copper-catalyzed C(sp³)─H functionalization reaction. This method represents a significant advancement in the field, as it does not require any exogenous acid or base, and the reaction can be completed within 2 h. A variety of N-formamidomethylated sulfonamides were synthesized in moderate to high yields. Hitherto, no prior reports have been found in the literature for the sulfonamidation of N,N-dimethyl formamide, making this reaction an important breakthrough in synthetic organic chemistry.