Sleep quality modifies and mediates the association between the oxidative balance score and depression: A cross-sectional study of NHANES 2007–2014

IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2025-06-30 DOI:10.1016/j.jad.2025.119762

Chen Chen , Keyu Pan , Chenzhuo Wu , Fengyuan Su , Wei Wang , Wen-Yang Li

{"title":"Sleep quality modifies and mediates the association between the oxidative balance score and depression: A cross-sectional study of NHANES 2007–2014","authors":"Chen Chen , Keyu Pan , Chenzhuo Wu , Fengyuan Su , Wei Wang , Wen-Yang Li","doi":"10.1016/j.jad.2025.119762","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Oxidative balance score (OBS) integrates dietary/lifestyle factors influencing oxidative stress. While linked to sleep quality and depression, whether sleep mediates the OBS-depression relationship remains unexplored.</div></div><div><h3>Methods</h3><div>Utilizing NHANES 2007–2014 data (<em>n</em> = 11,383), we calculated OBS from 20 pro−/antioxidant exposures. Sleep metrics included duration, self-reported trouble sleeping, and doctor-told sleep disorder. Depressive symptoms were assessed via PHQ–9. Weighted logistic regression, restricted cubic spline (RCS), and mediation analyses were conducted.</div></div><div><h3>Results</h3><div>The highest OBS quartile associated with reduced depression risk (OR = 0.22, 95%CI = 0.15–0.32), RCS analysis confirmed a non-linear relationship (<em>P</em> for nonlinear = 0.040). Similarly, higher OBS correlated with lower odds of unhealthy sleep patterns (OR = 0.54, 0.42–0.69), sleep disorders (OR = 0.67, 0.47–0.96), trouble sleeping (OR = 0.70, 0.55–0.90), and suboptimal duration (OR = 0.49, 0.38–0.61). There was an interaction between OBS and sleep disorder on depression (<em>P</em> for interaction = 0.039). Progressive depression risk reduction across OBS quartiles occurred in non-sleep-disordered individuals (<em>P</em> for trend<0.001; Q4 vs Q1: OR = 0.24, 0.16–0.36), versus protection limited to Q4 in sleep-disordered group (OR = 0.37, 0.16–0.86; <em>P</em> for trend = 0.059). Mediation analysis indicated partial mediation through sleep pattern (13.1 %), disorders (4.5 %), trouble sleeping (6.3 %), and abnormal duration (8.0 %) between OBS and depression.</div></div><div><h3>Conclusion</h3><div>Sleep quality mediates and modifies OBS-depression associations, with RCS revealing non-linear dynamics. Dual targeting of oxidative balance and sleep improvement may optimize depression prevention.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"390 ","pages":"Article 119762"},"PeriodicalIF":4.9000,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032725012042","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Oxidative balance score (OBS) integrates dietary/lifestyle factors influencing oxidative stress. While linked to sleep quality and depression, whether sleep mediates the OBS-depression relationship remains unexplored.

Methods

Utilizing NHANES 2007–2014 data (n = 11,383), we calculated OBS from 20 pro−/antioxidant exposures. Sleep metrics included duration, self-reported trouble sleeping, and doctor-told sleep disorder. Depressive symptoms were assessed via PHQ–9. Weighted logistic regression, restricted cubic spline (RCS), and mediation analyses were conducted.

Results

The highest OBS quartile associated with reduced depression risk (OR = 0.22, 95%CI = 0.15–0.32), RCS analysis confirmed a non-linear relationship (P for nonlinear = 0.040). Similarly, higher OBS correlated with lower odds of unhealthy sleep patterns (OR = 0.54, 0.42–0.69), sleep disorders (OR = 0.67, 0.47–0.96), trouble sleeping (OR = 0.70, 0.55–0.90), and suboptimal duration (OR = 0.49, 0.38–0.61). There was an interaction between OBS and sleep disorder on depression (P for interaction = 0.039). Progressive depression risk reduction across OBS quartiles occurred in non-sleep-disordered individuals (P for trend<0.001; Q4 vs Q1: OR = 0.24, 0.16–0.36), versus protection limited to Q4 in sleep-disordered group (OR = 0.37, 0.16–0.86; P for trend = 0.059). Mediation analysis indicated partial mediation through sleep pattern (13.1 %), disorders (4.5 %), trouble sleeping (6.3 %), and abnormal duration (8.0 %) between OBS and depression.

Conclusion

Sleep quality mediates and modifies OBS-depression associations, with RCS revealing non-linear dynamics. Dual targeting of oxidative balance and sleep improvement may optimize depression prevention.

查看原文本刊更多论文

睡眠质量调节并中介氧化平衡评分与抑郁之间的关系：NHANES 2007-2014的横断面研究

氧化平衡评分（OBS）综合了影响氧化应激的饮食/生活方式因素。虽然睡眠与睡眠质量和抑郁有关，但睡眠是否介导obs -抑郁关系仍未被研究。方法利用NHANES 2007-2014数据（n = 11,383），计算20例pro - /抗氧化剂暴露的OBS。睡眠指标包括持续时间、自我报告的睡眠问题和医生告诉的睡眠障碍。通过PHQ-9评估抑郁症状。进行了加权逻辑回归、限制三次样条（RCS）和中介分析。结果最高OBS四分位数与抑郁风险降低相关（OR = 0.22, 95%CI = 0.15 ~ 0.32）， RCS分析证实两者存在非线性关系（P = 0.040）。同样，较高的OBS与较低的不健康睡眠模式（OR = 0.54, 0.42-0.69）、睡眠障碍（OR = 0.67, 0.47-0.96）、睡眠问题（OR = 0.70, 0.55-0.90）和次优持续时间（OR = 0.49, 0.38-0.61）相关。OBS与睡眠障碍对抑郁有交互作用（交互作用P = 0.039）。无睡眠障碍的个体在OBS四分位数中出现进行性抑郁风险降低(P代表趋势<；0.001；Q4 vs Q1: OR = 0.24, 0.16-0.36)，而睡眠障碍组的保护仅限于Q4 (OR = 0.37, 0.16-0.86；P代表趋势= 0.059)。通过睡眠模式（13.1%）、障碍（4.5%）、睡眠困难（6.3%）和异常持续时间（8.0%）在OBS与抑郁之间起到部分调解作用。结论睡眠质量介导和调节obs -抑郁相关性，且RCS呈非线性动态变化。氧化平衡和睡眠改善的双重目标可能优化抑郁症的预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.