Clinical management and outcome of Meniere’s disease in children and adolescents: A systematic review

IF 1.3 4区医学 Q3 OTORHINOLARYNGOLOGY

International journal of pediatric otorhinolaryngology Pub Date : 2025-06-26 DOI:10.1016/j.ijporl.2025.112449

Jeyasakthy Saniasiaya, Narayanan Prepageran

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引用次数: 0

Abstract

Introduction

Meniere's disease (MD), or idiopathic endolymphatic hydrops, has been well-established in adults. However, due to the lack of understanding of pathomechanism and the progression of MD in children, managing this condition remains a challenge. The review aims to investigate the clinical management and outcome of treatments in children and adolescents with MD.

Methods

A systematic literature review was conducted in accordance with PRISMA guidelines to identify articles that assessed the outcome of treatment among children with MD. Information regarding the child's demographic data, MD symptoms, investigations, treatment, and outcomes was extracted from the included studies. The primary outcome was defined as the success of treatment based on the resolution or improvements of symptoms, while the secondary outcome was determined by recurrence or worsening symptoms or the presence of complications.

Results

The review included 12 studies published between 1958 and 2024. Fifty-seven children were noted, with a mean age of 9.9 ± 3.1 (range 5–14 years) and female predominance (60 %). Most of the included articles were from Asian countries (66.6 %), followed by Europe (16.7 %) and the USA (16.7 %). Improvement of symptoms was reported in 91.7 % of the included studies, with recurrence reported in four studies and persistence in symptoms found in one study. Diuretics were the most favoured intervention. Endolymphatic sac decompression is the favoured surgical option. Complications reported include worsening hearing found in two children (3.5 %).

Conclusion

Pharmacological and surgical treatment results in good outcomes in children with MD. However, the quality of the evidence is inadequate to recommend the ideal intervention until a better-quality study has been completed. Future randomised controlled studies with a large sample size are warranted to determine the ideal intervention in children with MD.

查看原文本刊更多论文

儿童和青少年梅尼埃病的临床治疗和预后：一项系统综述

梅尼埃病（MD），或特发性内淋巴积液，已在成人中得到证实。然而，由于缺乏对儿童MD的病理机制和进展的了解，管理这种情况仍然是一个挑战。本综述旨在调查儿童和青少年MD的临床管理和治疗结果。方法根据PRISMA指南进行系统的文献综述，以确定评估MD儿童治疗结果的文章。从纳入的研究中提取有关儿童人口统计学数据、MD症状、调查、治疗和结果的信息。主要结局被定义为基于症状缓解或改善的治疗成功，而次要结局由症状复发或恶化或并发症的存在决定。该综述包括了1958年至2024年间发表的12项研究。57例患儿，平均年龄9.9±3.1岁（5-14岁），以女性为主（60%）。被收录的文章大部分来自亚洲国家（66.6%），其次是欧洲（16.7%）和美国（16.7%）。91.7%的纳入研究报告症状改善，4项研究报告复发，1项研究发现症状持续存在。利尿剂是最受欢迎的干预措施。内淋巴囊减压是首选的手术选择。报告的并发症包括两名儿童（3.5%）的听力恶化。结论：药物和手术治疗对儿童MD有良好的疗效。然而，在一项质量更好的研究完成之前，证据的质量不足以推荐理想的干预措施。未来有必要进行大样本量的随机对照研究，以确定MD儿童的理想干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of pediatric otorhinolaryngology 医学-耳鼻喉科学

CiteScore

3.20

自引率

6.70%

发文量

276

审稿时长

62 days

期刊介绍： The purpose of the International Journal of Pediatric Otorhinolaryngology is to concentrate and disseminate information concerning prevention, cure and care of otorhinolaryngological disorders in infants and children due to developmental, degenerative, infectious, neoplastic, traumatic, social, psychiatric and economic causes. The Journal provides a medium for clinical and basic contributions in all of the areas of pediatric otorhinolaryngology. This includes medical and surgical otology, bronchoesophagology, laryngology, rhinology, diseases of the head and neck, and disorders of communication, including voice, speech and language disorders.