Silver@halloysite@chitosan composite antibacterial agent with pH-response and sustained releasing silver ions

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-06-30 DOI:10.1016/j.matlet.2025.139000

Hong Zhang , Xiong Zhang , Jiahao Li , Yifan Zan , Jinsheng Liang

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Abstract

This study constructed a novel pH-responsive sustained release composite antibacterial agent, silver@halloysite@chitosan (Ag@HNT@CTs), with a core–shell structure by loading silver nanoparticles onto the HNT and subsequently coating the HNT with chitosan. The CTs shell served as a pH-sensitive gatekeeper to release Ag⁺ because of the bacterial-induced acidic environment, and contracts to suppress Ag⁺ release under neutral and alkaline conditions. Colony counting assays revealed that Ag@HNT@CTs achieved 100 % antibacterial rates against E. coli and S. aureus within 5 h and 4 h, respectively. The minimum inhibitory concentration values of Ag@HNT@CTs were 250 μg/mL (E. coli) and 107 μg/mL (S. aureus). Also, the Ag@HNT@CTs composite material exhibited highly efficient antibacterial properties for 28 days. Ag@HNT@CTs is an antibacterial system featuring microenvironment responsiveness and sustained release, with promising applications in the architectural coatings, marine antifouling and medical fields.

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Silver@halloysite@壳聚糖复合ph响应缓释银离子抗菌剂

本研究通过将银纳米粒子加载到HNT上，然后在HNT上涂覆壳聚糖，构建了一种新型的ph响应型缓释复合抗菌剂silver@halloysite@壳聚糖（Ag@HNT@CTs）。由于细菌诱导的酸性环境，CTs外壳作为ph敏感的看门人释放Ag+，并在中性和碱性条件下收缩以抑制Ag+的释放。菌落计数实验显示，Ag@HNT@ ct分别在5 h和4 h内对大肠杆菌和金黄色葡萄球菌的抗菌率达到100%。Ag@HNT@ ct的最低抑菌浓度分别为250 μg/mL（大肠杆菌）和107 μg/mL（金黄色葡萄球菌）。此外，Ag@HNT@CTs复合材料在28天内表现出高效的抗菌性能。Ag@HNT@CTs是一种具有微环境响应性和缓释性的抗菌体系，在建筑涂料、船舶防污和医疗领域具有广阔的应用前景。

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive