Enantioselective electroreductive alkyne-aldehyde coupling

IF 14.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2025-07-01 DOI:10.1038/s41467-025-60230-5

Xiyang Cao, Yuyang Fu, Yongsheng Tao, Qingquan Lu

引用次数: 0

Abstract

Electrocatalytic methods that facilitate the asymmetric reductive coupling of two π-components with complete control over regio-, stereo-, and enantioselectivity remain underexplored. Herein, we report a highly regio- and enantioselective cobaltaelectro-catalyzed alkyne-aldehyde coupling reaction, in which protons and electrons serve as the hydrogen source and reductant, respectively. Earth-abundant cobalt and air-stable (S,S)−2,3-bis(tert-butylmethylphosphino)quinoxaline (QuinoxP*) are used as the catalyst and ligand, respectively. A series of enantioenriched allylic alcohols can be constructed with excellent regio- (>19:1), stereo- (>19:1 E:Z), and enantioselectivity (up to 98% ee).

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对映选择性电还原炔醛偶联

电催化方法促进了两个π-组分的不对称还原偶联，并完全控制了区域、立体和对映体选择性，但仍未得到充分的研究。在此，我们报道了一个高度区域选择性和对映选择性的钴电催化炔醛偶联反应，其中质子和电子分别作为氢源和还原剂。地球上丰富的钴和空气稳定的（S，S）−2,3-双（叔丁基甲基膦）喹啉（QuinoxP*）分别用作催化剂和配体。可以构建一系列对映体富集的烯丙醇，具有优异的区域- (>19:1)、立体- (>19:1 E:Z)和对映体选择性（高达98% ee）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.