Igor Longobardi, Bruna Caruso Mazzolani, Hamilton Roschel, Bruno Gualano, Alexandre Saadeh
{"title":"The global rollback of transgender care, science and rights","authors":"Igor Longobardi, Bruna Caruso Mazzolani, Hamilton Roschel, Bruno Gualano, Alexandre Saadeh","doi":"10.1038/s41591-025-03805-5","DOIUrl":null,"url":null,"abstract":"<p>Gender-affirming care for transgender youth is under attack. From Europe to the Americas, governments and professional bodies have imposed sweeping restrictions on essential medical interventions, bypassing scientific and ethical standards. Although framed as protective or cautious, these policies are neither: they misrepresent evidence, disregard international clinical guidelines, and expose vulnerable populations to harm.</p><p>This rollback is not isolated. In 2024–2025, the UK, USA and Brazil — three of the world’s largest democracies — enacted or reinforced limits on gender-affirming care. Despite differing sociopolitical contexts, they share key features: selective use of scientific uncertainty, erosion of clinical autonomy, and marginalization of trans voices in policymaking.</p>","PeriodicalId":19037,"journal":{"name":"Nature Medicine","volume":"32 1","pages":""},"PeriodicalIF":58.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41591-025-03805-5","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Gender-affirming care for transgender youth is under attack. From Europe to the Americas, governments and professional bodies have imposed sweeping restrictions on essential medical interventions, bypassing scientific and ethical standards. Although framed as protective or cautious, these policies are neither: they misrepresent evidence, disregard international clinical guidelines, and expose vulnerable populations to harm.
This rollback is not isolated. In 2024–2025, the UK, USA and Brazil — three of the world’s largest democracies — enacted or reinforced limits on gender-affirming care. Despite differing sociopolitical contexts, they share key features: selective use of scientific uncertainty, erosion of clinical autonomy, and marginalization of trans voices in policymaking.
期刊介绍:
Nature Medicine is a monthly journal publishing original peer-reviewed research in all areas of medicine. The publication focuses on originality, timeliness, interdisciplinary interest, and the impact on improving human health. In addition to research articles, Nature Medicine also publishes commissioned content such as News, Reviews, and Perspectives. This content aims to provide context for the latest advances in translational and clinical research, reaching a wide audience of M.D. and Ph.D. readers. All editorial decisions for the journal are made by a team of full-time professional editors.
Nature Medicine consider all types of clinical research, including:
-Case-reports and small case series
-Clinical trials, whether phase 1, 2, 3 or 4
-Observational studies
-Meta-analyses
-Biomarker studies
-Public and global health studies
Nature Medicine is also committed to facilitating communication between translational and clinical researchers. As such, we consider “hybrid” studies with preclinical and translational findings reported alongside data from clinical studies.