FOXP3 dependence

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-06-30 DOI:10.1038/s41590-025-02213-8

Ioana Staicu

引用次数: 0

查看原文本刊更多论文

FOXP3的依赖

调节性T （Treg）细胞是否持续依赖于FOXP3尚不清楚。科学免疫学,贼鸥等人使用转基因小鼠模型(Foxp3AID老鼠),使化学诱导退化(55 - 95%)Treg FOXP3蛋白质的细胞继续GFP + FOXP3结果表明损失在CD25表达降低,但维护GFP + Treg脾脏细胞数量和non-lymphoid组织至少10天,增加传统T (Tconv)细胞CD4 +, CD8 + T细胞和生产干扰素γ、il - 4和IL-17脾,但不是在组织。相比之下，在自身免疫、病毒感染或癌症的情况下，Treg细胞中FOXP3的缺失会导致GFP+ Treg细胞的缺失（尤其是前两种情况下的GFP+CXCR3+ Treg细胞亚群）和CD4+ Tconv细胞和CD8+ T细胞的扩增。在炎症激活的Treg细胞中，FOXP3缺失诱导编码转录因子、信号分子和细胞表面蛋白的基因差异表达（主要是上调），而在稳态Treg细胞中影响最小，这表明FOXP3具有激活依赖性，主要是抑制性的基因调控功能。原始参考文献：Sci。Immunol。https://doi.org/10.1126/sciimmunol.adr7057 (2025)

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.