Rare Infectious Diseases: Detection and Clinical Implications

iLABMED Pub Date : 2025-05-30 DOI:10.1002/ila2.70019
Xin Qian, Yuxin Zhang, Yilin Ye, Qiange Lin, Junyou Lin, Xinrong Lu, Li Chen, Guiqin Sun
{"title":"Rare Infectious Diseases: Detection and Clinical Implications","authors":"Xin Qian,&nbsp;Yuxin Zhang,&nbsp;Yilin Ye,&nbsp;Qiange Lin,&nbsp;Junyou Lin,&nbsp;Xinrong Lu,&nbsp;Li Chen,&nbsp;Guiqin Sun","doi":"10.1002/ila2.70019","DOIUrl":null,"url":null,"abstract":"<p>Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross-species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis. Traditional detection techniques such as microbial cultivation and isolation or polymerase chain reaction often fail to meet the clinical demands for timeliness, accuracy, and sensitivity. Metagenomic next-generation sequencing involves pan-nucleic acid testing conducted directly using specimens to facilitate rapid identification of rare or unidentified pathogens. Despite the availability of various techniques, advanced methods in clinical practice are necessary to achieve timely clinical diagnosis of rare infections. In this review, we summarize the definition and clinical significance of rare infectious diseases as well as the current detection methods, limitations, and future research areas for their detection.</p>","PeriodicalId":100656,"journal":{"name":"iLABMED","volume":"3 2","pages":"148-157"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ila2.70019","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"iLABMED","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ila2.70019","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Rare infectious diseases are infections that are uncommon, have a low incidence, and are caused by newly emerging pathogens, cross-species or ectopic infections, or host immunodeficiencies. The detection and diagnosis of rare infections is one of the main reasons for misdiagnosis and missed diagnosis. Traditional detection techniques such as microbial cultivation and isolation or polymerase chain reaction often fail to meet the clinical demands for timeliness, accuracy, and sensitivity. Metagenomic next-generation sequencing involves pan-nucleic acid testing conducted directly using specimens to facilitate rapid identification of rare or unidentified pathogens. Despite the availability of various techniques, advanced methods in clinical practice are necessary to achieve timely clinical diagnosis of rare infections. In this review, we summarize the definition and clinical significance of rare infectious diseases as well as the current detection methods, limitations, and future research areas for their detection.

罕见传染病:检测和临床意义
罕见传染病是指由新出现的病原体、跨种或异位感染或宿主免疫缺陷引起的不常见、发病率低的感染。罕见感染的发现和诊断是造成误诊和漏诊的主要原因之一。传统的微生物培养分离或聚合酶链反应等检测技术往往不能满足临床对及时性、准确性和敏感性的要求。新一代宏基因组测序涉及使用标本直接进行的泛核酸检测,以促进快速鉴定罕见或未识别的病原体。尽管各种技术的可用性,但在临床实践中需要先进的方法来实现罕见感染的及时临床诊断。本文就罕见传染病的定义、临床意义、目前罕见传染病的检测方法、局限性及未来的研究方向进行综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信